Protein Mutations Consequences On Structure Function And Diseases
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Protein Mutations Consequences On Structure Functions And Diseases
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Author : M Michael Gromiha
language : en
Publisher: World Scientific
Release Date : 2024-10-02
Protein Mutations Consequences On Structure Functions And Diseases written by M Michael Gromiha and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-02 with Science categories.
Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations.The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.
Protein Mutations Consequences On Structure Function And Diseases
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Author : M Michael Gromiha
language : en
Publisher:
Release Date : 2024-09-29
Protein Mutations Consequences On Structure Function And Diseases written by M Michael Gromiha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-29 with Science categories.
Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations. The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Protein Dysfunction In Human Genetic Disease
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Author : D M Swallow
language : en
Publisher: Taylor & Francis
Release Date : 2024-11-15
Protein Dysfunction In Human Genetic Disease written by D M Swallow and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-15 with Medical categories.
Recent years have seen rapid advances in our understanding of genetic diseases in terms of their molecular origins. The book focuses on DNA mutations which give rise to abnormalities of protein structure and function in genetic disease.
Retinal Degenerative Diseases
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Author : Robert E. Anderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-19
Retinal Degenerative Diseases written by Robert E. Anderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-19 with Medical categories.
This is the proceedings of the XIIIth International Symposium on Retinal Degenerations, which will be held in Emeishan, Sichuan, China on September 18 - 23, 2008. The themes will include "Molecular and genetic mechanisms in photoreceptor degeneration", "Age-related macular degeneration", "New diagnostic techniques for retinal degenerations". "Neuroprotection in the prevention of retinal degeneration", "Gene therapy and the correction of gene defects", as well as other emerging topics that may develop over the next few months.
Computational And Experimental Protein Variant Interpretation In The Era Of Precision Medicine
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Author : Daniele Dell'Orco
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Computational And Experimental Protein Variant Interpretation In The Era Of Precision Medicine written by Daniele Dell'Orco and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
One of the key goals in the postgenomic era is the elucidation of the mechanisms underlying the relationship between genotype and phenotype. In particular, understanding how human genetic and somatic variations are associated with diseases is still an open problem and its solution is a crucial issue for exploiting the possibilities offered by the modern sequencing techniques in the framework of precision and personalized medicine. The increasing amount of data generated by the sequencing initiatives calls for accurate and reliable computational approaches to predict the impact of mutations on the phenotype, and possibly for methods to correlate them with diseases. From the experimental point of view, disease-causing variants are supposed to directly affect protein function, protein stability as well as the kinetics and thermodynamics of protein-protein recognition, and robust validation at the molecular scale is necessary. This approach can be of invaluable help in facing new challenges such as the fast development of effective vaccines.
Dancing Protein Clouds Intrinsically Disordered Proteins In Health And Disease Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-09-12
Dancing Protein Clouds Intrinsically Disordered Proteins In Health And Disease Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-12 with Science categories.
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
Approaches Of Computational Biophysics And Chemistry In Molecular Biology
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Author : Emil Alexov
language : en
Publisher: World Scientific
Release Date : 2025-01-17
Approaches Of Computational Biophysics And Chemistry In Molecular Biology written by Emil Alexov and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-17 with Science categories.
This book covers a broad range of computational biophysics and chemistry methods and their applications to study various phenomena in molecular biology. Highlighting recent advances, it emphasizes enhanced modeling accuracy, longer timescales, and the ability to simulate large biological macromolecules. From molecular dynamics simulations to quantum mechanical methods, the book discusses innovations like polarizable force fields and the integration of machine learning (ML) and artificial intelligence (AI) for improved predictive accuracy. It examines how these techniques predict the pKa of ionizable groups in biological macromolecules such as proteins, DNAs, and RNAs. It is demonstrated that the abovementioned computational techniques can be used to infer the pathogenicity of DNA variants and to reveal the molecular mechanism of diseases.By providing extensive coverage of various methods and diverse applications, this book is a valuable resource that links computational approaches to understanding molecular effects in human diseases, ultimately advancing the field of personalized medicine.
Advances In Protein Molecular And Structural Biology Methods
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Author : Timir Tripathi
language : en
Publisher: Academic Press
Release Date : 2022-01-14
Advances In Protein Molecular And Structural Biology Methods written by Timir Tripathi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-14 with Science categories.
Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. - Presents a thorough overview of the latest and emerging methods and technologies for protein study - Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy - Includes computational and machine learning methods - Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins
Computational Approaches To Study The Impact Of Mutations On Disease And Drug Resistance
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Author : Nir Ben-Tal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Computational Approaches To Study The Impact Of Mutations On Disease And Drug Resistance written by Nir Ben-Tal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.