Protein Mutations Consequences On Structure Functions And Diseases
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Protein Mutations Consequences On Structure Functions And Diseases
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Author : M Michael Gromiha
language : en
Publisher: World Scientific
Release Date : 2024-10-02
Protein Mutations Consequences On Structure Functions And Diseases written by M Michael Gromiha and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-02 with Science categories.
Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations.The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.
Protein Mutations Consequences On Structure Function And Diseases
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Author : M Michael Gromiha
language : en
Publisher:
Release Date : 2024-09-29
Protein Mutations Consequences On Structure Function And Diseases written by M Michael Gromiha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-29 with Science categories.
Proteins perform various functions in living organisms. However, any mutation in the amino acid residues of a protein affects its structure and function. Some of these mutations may lead to diseases. These disease-causing mutations have an impact on protein structure, stability, and its binding affinity to complexes. Moreover, the study of amino acid mutation in proteins is important for developing therapeutic strategies. It is a pertinent and timely endeavor to provide comprehensive insights on the consequences of these mutations. The main highlights of this book are the effects of protein mutations on its various functions such as aggregation, folding, stability, binding affinity, and diseases, as well as a wide range of applications such as database development, computational algorithms, and drug design. It will be a platform to provide the up-to-date information and latest developments in the field and will serve as a single resource to get the information on comparative studies to delineate these mutational effects on protein folding, stability, and interactions, and for understanding the molecular basis of diseases.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Computational Approaches To Study The Impact Of Mutations On Disease And Drug Resistance
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Author : Nir Ben-Tal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Computational Approaches To Study The Impact Of Mutations On Disease And Drug Resistance written by Nir Ben-Tal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
Approaches Of Computational Biophysics And Chemistry In Molecular Biology
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Author : Emil Alexov
language : en
Publisher: World Scientific
Release Date : 2025-01-17
Approaches Of Computational Biophysics And Chemistry In Molecular Biology written by Emil Alexov and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-17 with Science categories.
This book covers a broad range of computational biophysics and chemistry methods and their applications to study various phenomena in molecular biology. Highlighting recent advances, it emphasizes enhanced modeling accuracy, longer timescales, and the ability to simulate large biological macromolecules. From molecular dynamics simulations to quantum mechanical methods, the book discusses innovations like polarizable force fields and the integration of machine learning (ML) and artificial intelligence (AI) for improved predictive accuracy. It examines how these techniques predict the pKa of ionizable groups in biological macromolecules such as proteins, DNAs, and RNAs. It is demonstrated that the abovementioned computational techniques can be used to infer the pathogenicity of DNA variants and to reveal the molecular mechanism of diseases.By providing extensive coverage of various methods and diverse applications, this book is a valuable resource that links computational approaches to understanding molecular effects in human diseases, ultimately advancing the field of personalized medicine.
Biochemical Physiological And Molecular Aspects Of Human Nutrition E Book
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Author : Martha H. Stipanuk
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-04-06
Biochemical Physiological And Molecular Aspects Of Human Nutrition E Book written by Martha H. Stipanuk and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-06 with Medical categories.
A scientific look at the biological bases of human nutrition. Covering advanced nutrition with a comprehensive, easy-to-understand approach, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 4th Edition, focuses on nutrition at the molecular, cellular, tissue, and whole-body levels. Written by Martha Stipanuk, Marie Caudill, and a team of nutrition experts, the text addresses nutrients by classification, and describes macronutrient function from digestion to metabolism. This edition includes the most current recommendations from the Dietary Guidelines for Americans, plus coverage of the historical evolution of nutrition and information on a wide range of vitamins, minerals, and other food components. - More than 20 expert contributors provide the latest information on all areas of the nutrition sciences. - Thinking Critically sections within boxes and at the end of chapters help in applying scientific knowledge to "real-life" situations. - Common Abbreviations for the entire book are listed alphabetically on the inside back cover for easy reference. - Nutrition Insight boxes discuss hot topics and take a closer look at basic science and everyday nutrition. - Clinical Correlation boxes show the connection between nutrition-related problems and their effects on normal metabolism. - Food Sources boxes summarize and simplify data from the USDA National Nutrient Database on the amount and types of foods needed to reach the recommended daily allowances for vitamins and minerals. - DRIs Across the Life Cycle boxes highlight the latest data from the Institute of Medicine on dietary reference intakes for vitamins and minerals, including coverage of infants, children, adult males and females, and pregnant and lactating women. - Historical Tidbit boxes provide a historical context to key nutritional findings. - NEW! Thoroughly updated art program helps to clarify complex concepts. - NEW! Select bolded summary headings enable students to efficiently review information and recognize major messages - NEW! Content updated throughout incorporates the latest research and findings, including extensively revised coverage of lipids, lipoproteins, cholesterol, fatty acids, and triacylglycerol metabolism. - NEW! Improved writing style makes the material more concise, direct, and accessible. - NEW! Additional boxes, tables, and critical thinking questions break up the narrative and reinforce key concepts.
Function And Flexibility Friend Or Foe
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Author : Kris Pauwels
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-06
Function And Flexibility Friend Or Foe written by Kris Pauwels and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-06 with Science (General) categories.
Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.
Protein Dysfunction In Human Genetic Disease
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Author : D M Swallow
language : en
Publisher: Taylor & Francis
Release Date : 2024-11-15
Protein Dysfunction In Human Genetic Disease written by D M Swallow and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-15 with Medical categories.
Recent years have seen rapid advances in our understanding of genetic diseases in terms of their molecular origins. The book focuses on DNA mutations which give rise to abnormalities of protein structure and function in genetic disease.
Revolutionizing Life Sciences The Nobel Leap In Artificial Intelligence Driven Biomodeling
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Author : Valentina Tozzini
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-22
Revolutionizing Life Sciences The Nobel Leap In Artificial Intelligence Driven Biomodeling written by Valentina Tozzini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-22 with Science categories.
The year 2024 marked a historic milestone in the advancement of Artificial Intelligence (AI) as it saw the awarding of Nobel prizes specifically recognizing groundbreaking AI technologies. These technologies not only revolutionized traditional disciplines but also significantly enhanced capabilities within the biological sciences. By mapping the interfaces where AI meets molecular biology, this Research Topic intends to serve as a benchmark for current capabilities, a guideline for overcoming existing challenges, and a vision board for future opportunities that could further push the boundaries of what is scientifically possible in molecular biosciences. Keywords: deep-learning, neur
Actin Binding Proteins And Disease
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Author : Cris dos Remedios
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-08
Actin Binding Proteins And Disease written by Cris dos Remedios and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Science categories.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.