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Proteoform Identification


Proteoform Identification
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Proteoform Identification


Proteoform Identification
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Author : Liangliang Sun
language : en
Publisher: Humana
Release Date : 2022-07-04

Proteoform Identification written by Liangliang Sun and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-04 with Science categories.


This volume discusses the latest mass spectrometry (MS)-based technologies for proteoform identification, characterization, and quantification. Some of the topics covered in this book include sample preparation, proteoform separation, proteoform gas-phase fragmentation, and bioinformatics tools for MS data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Proteoform Identification: Methods and Protocols is a valuable resource for researchers in both academia and the biopharmaceutical industry who are interested in proteoform analysis using MS.



Proteoforms


Proteoforms
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Author : Xianquan Zhan
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-15

Proteoforms written by Xianquan Zhan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-15 with Science categories.


A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.



Algorithms In Bioinformatics


Algorithms In Bioinformatics
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Author : Martin Frith
language : en
Publisher: Springer
Release Date : 2016-08-08

Algorithms In Bioinformatics written by Martin Frith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Computers categories.


This book constitutes the refereed proceedings of the 16th International Workshop on Algorithms in Bioinformatics, WABI 2016, held in Aarhus, Denmark. The 25 full papers together with 2 invited talks presented were carefully reviewed and selected from 54 submissions. The selected papers cover a wide range of topics from networks, tophylogenetic studies, sequence and genome analysis, comparative genomics, and mass spectrometry data analysis.



Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics


Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics
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Author : Rawi Ramautar
language : en
Publisher: John Wiley & Sons
Release Date : 2022-10-11

Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics written by Rawi Ramautar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-11 with Science categories.


Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.



Bioinformatics Research And Applications


Bioinformatics Research And Applications
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Author : Zhipeng Cai
language : en
Publisher: Springer
Release Date : 2017-05-29

Bioinformatics Research And Applications written by Zhipeng Cai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-29 with Computers categories.


This book constitutes the proceedings of the 13th International Symposium on Bioinformatics Research and Applications, ISBRA 2017, held in Honolulu, HI, USA, in May/June 2017. The 27 full papers presented together with 18 short papers and 24 invited abstracts were carefully reviewed and selected from 131 submissions. They cover topics such as: biomarker discovery; biomedical databases and data integration; biomedical text mining and ortologies; biomolecular imaging; comparative genomics; computational genetic epidemiology; computational proteomics; data mining and visualization; gene expression analysis; genome analysis; high-performance bio-computing; metagenomics; molecular evolution; molecular modelling and simulation; next-generation sequencing data analysis; pattern discovery and classification; population genetics; software tools and applications; structural biology; and systems biology.



Detection And Analysis Of Microorganisms By Mass Spectrometry


Detection And Analysis Of Microorganisms By Mass Spectrometry
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Author : Jia Yi
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-10-06

Detection And Analysis Of Microorganisms By Mass Spectrometry written by Jia Yi and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-06 with Science categories.




Proteomic And Metabolomic Approaches To Biomarker Discovery


Proteomic And Metabolomic Approaches To Biomarker Discovery
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Author : Haleem J. Issaq
language : en
Publisher: Academic Press
Release Date : 2019-10-24

Proteomic And Metabolomic Approaches To Biomarker Discovery written by Haleem J. Issaq and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Science categories.


Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students



Bioinformatics Research And Applications


Bioinformatics Research And Applications
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Author : Wei Peng
language : en
Publisher: Springer Nature
Release Date :

Bioinformatics Research And Applications written by Wei Peng and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.




Post Translational Modifications That Modulate Enzyme Activity


Post Translational Modifications That Modulate Enzyme Activity
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-10-12

Post Translational Modifications That Modulate Enzyme Activity written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-12 with Science categories.


Post-translational Modifications That Modulate Enzyme Activity, Volume 626 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Updated chapters include Crosstalk between cellular metabolism and histone acetylation, Isolation of protein complexes and modifications that regulate transcriptional machinery, High-throughput phosphoproteome mapping through multiplexed mass spectrometry, Differentiation of D and L epimerization in proteins, Biochemical analysis of protein arginylation, Site-specific Determination of lysine acetylation stoichiometries on the proteome-scale, Genomic and biochemical analysis of RNA post-transcriptional modifications, Isolation and characterization of glycosylated (neuro)peptides, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on Post-translational Modifications that Modulate Enzyme Activity



Capillary Electrophoresis Mass Spectrometry


Capillary Electrophoresis Mass Spectrometry
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Author : Christian Neusüß
language : en
Publisher: Springer Nature
Release Date : 2022-08-08

Capillary Electrophoresis Mass Spectrometry written by Christian Neusüß and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-08 with Science categories.


This volume details aspects and applications of interfacing capillary electrophoresis (CE) with mass spectrometry (MS). Chapters guide readers through approaches based on different types of CE-MS interfaces such as (nano)sheath liquid, porous tip, and liquid junction, as well as various capillary coatings, and a broad range of applications including several top-down and bottom-up proteomic approaches. Additionally, a list of analyte targets was provided consisting of amphetamines, antibiotics, carbohydrates (including glycosaminoglycans and glycopeptides), enantiomers, extracellular matrix metabolites, monoclonal antibodies, and nanoparticles, and therefore covers numerous fields of applications such as pharmaceutical, biomedical, food, agrochemical, and environmental analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Capillary Electrophoresis-Mass Spectrometry: Methods and Protocols aims to provide highly valuable information for both beginners and experts in the field be it students, technical staff, and scientists.