Purinergic Signaling And Inflammation
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Purinergic Signaling And Inflammation
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Author : Davide Ferrari
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-14
Purinergic Signaling And Inflammation written by Davide Ferrari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives
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Author : Rosa Gomez-Villafuertes
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives written by Rosa Gomez-Villafuertes and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.
Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration
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Author : Henning Ulrich
language : en
Publisher: Springer Nature
Release Date : 2023-07-16
Purinergic Signaling In Neurodevelopment Neuroinflammation And Neurodegeneration written by Henning Ulrich and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-16 with Medical categories.
This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club
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Author : Francesco Caciagli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club written by Francesco Caciagli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
Purinergic Signaling In Neuroinflammation
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Author : Dmitry Aminin
language : en
Publisher:
Release Date : 2023
Purinergic Signaling In Neuroinflammation written by Dmitry Aminin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity.
Purinergic Pharmacology
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Author : Francisco Ciruela
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Purinergic Pharmacology written by Francisco Ciruela and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Purinergic Signaling In Neuroinflammation
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Author : Dmitry Aminin
language : en
Publisher: Mdpi AG
Release Date : 2023-05-18
Purinergic Signaling In Neuroinflammation written by Dmitry Aminin and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-18 with Science categories.
It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity.
Purinergic Signaling In Health And Disease
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Author : Eric Boué-Grabot
language : en
Publisher:
Release Date : 2020
Purinergic Signaling In Health And Disease written by Eric Boué-Grabot and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Adenosine 5'-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy "currency." After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia.
Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses
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Author : Yong Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Purinergic Signalling In The Central Nervous System And Its Pharmacological Importance In Neurological And Psychiatric Illnesses written by Yong Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-storing molecule, but may also reach the extracellular space, where it participates in cell-to-cell signalling. For this purpose, ATP utilises a range of purinergic receptors activated either by ATP itself (P2X receptors; seven subtypes) or by ATP/ADP and UTP/UDP (P2Y receptors; 8 subtypes) and finally via its enzymatic degradation product, adenosine (P1/A receptors; 4 subtypes). Purine nucleotides and nucleosides together with the whole plethora of receptors and degrading enzymes constitute the purinome. This fascinating and extensive network exists both in the animal kingdom and in humans and is essential in regulating important physiological functions. Disturbances in the network can lead to a variety of illnesses clinically associated with both neurological or psychiatric traits. In recent years, hope has arisen that pharmacological chemistry together with various newly developed methods, will enable researchers to discover and design efficient drugs for treating these neurodegenerative and affective diseases.
Receptors P1 And P2 As Targets For Drug Therapy In Humans
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Author : Robson Faria
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Receptors P1 And P2 As Targets For Drug Therapy In Humans written by Robson Faria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.