Regulation And Functional Significance Of T Cell Subsets

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Regulation And Functional Significance Of T Cell Subsets

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Author : R. L. Coffman
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1992

Regulation And Functional Significance Of T Cell Subsets written by R. L. Coffman and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.

Generation And Effector Functions Of Regulatory Lymphocytes

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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2004-01-19

Generation And Effector Functions Of Regulatory Lymphocytes written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-19 with Science categories.

Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells. This book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transplantation and the control of viral infection. This important and groundbreaking book should be of interest to all immunologists. Related Novartis Foundation symposia: 254 Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee 256 Cancer and inflammation Chair: Siamon Gordon

Characterization Functions And Roles Of Antigen Specific Regulatory T Cells In Health And Disease

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Author : Giang Tran
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-09

Characterization Functions And Roles Of Antigen Specific Regulatory T Cells In Health And Disease written by Giang Tran and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-09 with Medical categories.

Signaling Mechanisms Regulating T Cell Diversity And Function

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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27

Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Role Of Metabolism In Regulating Immune Cell Fate Decisions

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Author : Anna Ohradanova-Repic
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-26

Role Of Metabolism In Regulating Immune Cell Fate Decisions written by Anna Ohradanova-Repic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-26 with categories.

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

T Cell Subsets In Infectious And Autoimmune Diseases

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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30

T Cell Subsets In Infectious And Autoimmune Diseases written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.

T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.

T Cell Regulation By The Environment

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Author : Anne L. Astier
language : en
Publisher: Frontiers Media SA
Release Date : 2015

T Cell Regulation By The Environment written by Anne L. Astier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Immunologic diseases. Allergy categories.

Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.

Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential

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Author : B. Kyewski
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-09

Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential written by B. Kyewski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-09 with Medical categories.

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Cumulated Index Medicus

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Author :
language : en
Publisher:
Release Date : 1982

Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medicine categories.

Science In Medicine

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Author : Ushma S. Neill
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2007-10-31

Science In Medicine written by Ushma S. Neill and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-31 with Medical categories.

Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers.