Regulation Of Axon Outgrowth And Guidance In C Elegans
DOWNLOAD
Download Regulation Of Axon Outgrowth And Guidance In C Elegans PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Regulation Of Axon Outgrowth And Guidance In C Elegans book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Regulation Of Axon Outgrowth And Guidance In C Elegans
DOWNLOAD
Author : Jennifer A. Zallen
language : en
Publisher:
Release Date : 1999
Regulation Of Axon Outgrowth And Guidance In C Elegans written by Jennifer A. Zallen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Genetic Analysis Of Axon Guidance And Branching In C Elegans
DOWNLOAD
Author : Joe C. Hao
language : en
Publisher:
Release Date : 2003
Genetic Analysis Of Axon Guidance And Branching In C Elegans written by Joe C. Hao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Cytoskeletal Signaling And The Regulation Of Attraction And Repulsive Axon Guidance In C Elegans
DOWNLOAD
Author : Timothy W. Yu
language : en
Publisher:
Release Date : 2001
Cytoskeletal Signaling And The Regulation Of Attraction And Repulsive Axon Guidance In C Elegans written by Timothy W. Yu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Axon Growth And Guidance
DOWNLOAD
Author : Dominique Bagnard
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-10
Axon Growth And Guidance written by Dominique Bagnard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-10 with Medical categories.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
An Investigation Of The Signaling Pathways That Control Cell Migration And Axon Guidance In Caenorhabditis Elegans
DOWNLOAD
Author : Mark Stephan Lucanic
language : en
Publisher:
Release Date : 2007
An Investigation Of The Signaling Pathways That Control Cell Migration And Axon Guidance In Caenorhabditis Elegans written by Mark Stephan Lucanic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity
DOWNLOAD
Author : Aseel Al-Aamiri
language : en
Publisher:
Release Date : 2017
Zag 1 A Zn Finger Homeodomain Transcription Factor Affects Neuronal Outgrowth Patterning By Regulating Unc 40 Dcc Mediated Outgrowth Activity written by Aseel Al-Aamiri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Axons categories.
Axon guidance is a fundamental process during animal nervous system development. For neurons to function correctly, they must be wired into their target areas. Several neurodevelopment disorders result from wiring defects. The guidance process is continuous, and outgrowth direction activity may fluctuate across the plasma membrane. We propose this process is statistically dependent. If the probability of axon outgrowth at one site changes then the probability at another site must change. The plasma membrane movement can be modeled by a random walk. Axon guidance process is regulated by many conserved extracellular guidance cues that can act as attractants or repellants, but how these guidance cues are regulated is still being researched. In Caenorhabditis elegans, the UNC-6/Netrin extracellular cue directs neuronal outgrowth. Neuronal response to UNC-6/Netrin is mediated by UNC-40/DCC and UNC-5/UNC5 receptors and the UNC-53/NAV2 cytoplasmic protein. My study provides evidence that links stochasticity with transcriptional regulation of axon guidance to regulate axon orientation at the transcriptional level. ZAG-1, a member of the ZEB family of transcription factors, affects neuronal outgrowth patterning by regulating UNC-40-mediated neuronal outgrowth activity. Understanding the functional relationship between transcription factors and the cell-surface and cytoskeletal proteins that mediate their effects is a current challenge in neurobiology. Here I present evidence that ZAG-1 and UNC-5 regulate UNC-40::GFP localization, axon outgrowth patterning, and the directional bias of axons by regulating the UNC-6/Netrin signaling pathway and UNC-53 activities. unc-5 mutations alter UNC-40::GFP asymmetric localization and axon outgrowth patterning that neurons develop. Genetic interactions suggest that UNC-5 and ZAG-1 act with UNC-53 to regulate axon outgrowth patterning and UNC-40::GFP asymmetric localization in response to extracellular guidance cues.
Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans
DOWNLOAD
Author : Nancy Marcus
language : en
Publisher:
Release Date : 2012
Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans written by Nancy Marcus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Actin categories.
The excretory cell is the functional equivalent to the kidney in the nematode Caenorhabditis elegans, and provides an excellent in vivo model to study directional cell migration and extension. The leading edges of the growing canals resemble neuronal growth cones in that they must be able to sense and integrate directional cues in both the dorsoventral and anteroposterior axes. The cytoskeleton regulator UNC-53/NAV2 is required for both the anterior and posterior outgrowth of several neurons, as well as the excretory cell. UNC-53 and the Abelson kinase interactor (ABI-1) appear to function cell autonomously in the excretory canals to promote outgrowth, have overlapping expression patterns, and display similar cell migration phenotypes in the canals and mechanosensory neurons. Moreover, proteins known to function with abi-1 in actin dynamics, including members of the ARP2/3 complex exhibit similar excretory cell and neuronal outgrowth defects by RNAi, suggesting that UNC-53 may act as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodelling. Genetic analysis of putative interactors of UNC-53 suggests that UNC-53 appears to function together with UNC-71/ADAM, while the kinesin-like motor VAB-8 appears to act in a separate pathway to control the posteriorly directed excretory canal outgrowth. Analysis of putative interactors of VAB-8 suggests that VAB-8, SAX-3/ROBO, SLT-1/Slit and EVA-1 are functioning together in the outgrowth of the excretory canals. The known VAB-8 interactor, the Rac/Rho GEF UNC-73/TRIO operates in both pathways, as isoform specific alleles exhibit enhancement of the phenotype in double mutant combination with either unc-53 or vab-8. Rescue experiments suggest that a cell autonomous pathway is mediated by the Rho specific GEF domain of the UNC-73E isoform in conjunction with UNC-53, UNC-71, and ABI-1, and a cell non-autonomous pathway is mediated by the Rac specific GEF domain of the UNC-73B isoform, through partnering with VAB-8 and the receptors SAX-3 and EVA-1. Taken together, my studies indicate that the migration of the excretory canals requires two or more signaling pathways, and the guidance cues involved are also essential migration molecules functioning to guide neuronal cells and axon growth cones.
Regulation Of Axon Length By Rpm 1 Via The Dlk 1 Signaling Pathway
DOWNLOAD
Author : Maria Fernanda Valverde da Silva
language : en
Publisher:
Release Date : 2011
Regulation Of Axon Length By Rpm 1 Via The Dlk 1 Signaling Pathway written by Maria Fernanda Valverde da Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Electronic books categories.
The formation of neuronal connections is a complex process that involves several key steps: initiation of the axon and growth cone, axon extension, target recognition, axon growth termination and formation of synapses. Subsequently, the axon must elongate to maintain its relative position and connectivity as the animal grows longer and larger. In C. elegans, the interneuron AVG is located near the head and extends two processes: a short anteriorly directed process and a long posteriorly directed process that pioneers the ventral nerve cord and extends to the tail. To identify genes controlling axon growth and guidance, I screened for mutants with defects in the length and pattern of the AVG processes. Five mutations were isolated that caused the posteriorly directed process to extend past its normal termination site. Four mutations were alleles of the gene rpm-1, which encodes a conserved E3 ubiquitin ligase that regulates axon termination of the mechanosensory neurons and presynaptic differentiation of GABAergic neurons. One mutation was an allele of the gene fsn-1, which encodes an F-box protein that interacts and functions with RPM-1. Our results indicate that RPM-1 and FSN-1 also regulate AVG axon extension. RPM-1 acts via two pathways to control mechanosensory neuron axon growth and presynaptic differentiation. RPM-1 works via an SCF-like ubiquitin ligase complex with FSN-1 to downregulate a DLK-1 MAP kinase cascade. RPM-1 also interacts with the guanine nucleotide exchange factor GLO-4 to positively regulate the Rab GTPase GLO-1 to influence vesicular trafficking of axon guidance receptors. In AVG, we found that RPM-1 does not act via the GLO-1/GLO-4 pathway but instead acts solely through the DLK-1 MAP kinase. By analyzing rpm-1 and fsn-1 mutants at different time points, we determined that these genes do not affect the initial outgrowth of AVG during embryogenesis; rather cause it to overextend during later larval stages. Mutation of vab-8, which encodes a kinesin related protein, blocks the posteriorly directed growth of axons, including AVG. In addition, we found that mutation of the Wnts EGL-20 and LIN-44 or the Wnt receptor LIN-17 caused the AVG axon to stop before its normal termination site. fsn-1 and rpm-1 mutations were able to overcome the embryonic axon growth defects present in vab-8, lin-17, lin-44 and lin-44; egl-20 mutants and allowed AVG over extension in larval stages. These results illustrate that RPM-1 does not regulate the initial outgrowth of the posteriorly directed AVG process, but rather acts to control its length during postembryonic development. The ability of RPM-1 to influence axon length is independent of the pathways used during the initial outgrowth in embryos. Further characterization of factors and pathways involved in AVG axon extension could lead to breakthroughs in neural developmental biology for the treatment of both cognitive and motor disabilities.
Cellular Migration And Formation Of Neuronal Connections
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Cellular Migration And Formation Of Neuronal Connections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Caenorhabditis Elegans
DOWNLOAD
Author : Henry F. Epstein
language : en
Publisher: Academic Press
Release Date : 1995
Caenorhabditis Elegans written by Henry F. Epstein and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Caenorhabditis elegans categories.
The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.