Research And Clinical Applications Of Targeting Gastric Neoplasms
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Research And Clinical Applications Of Targeting Gastric Neoplasms
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Author : Brendan Jenkins
language : en
Publisher: Academic Press
Release Date : 2021-07-17
Research And Clinical Applications Of Targeting Gastric Neoplasms written by Brendan Jenkins and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-17 with Science categories.
Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields. - Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer - Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics - Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach
Inherited Gastrointestinal Cancers Identification Management And The Role Of Genetic Evaluation And Testing An Issue Of Gastrointestinal Endoscopy Clinics E Book
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Author : Fay Kastrinos
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-11-26
Inherited Gastrointestinal Cancers Identification Management And The Role Of Genetic Evaluation And Testing An Issue Of Gastrointestinal Endoscopy Clinics E Book written by Fay Kastrinos and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
This issue of Gastrointestinal Endoscopy Clinics provides a multidisciplinary approach to the evaluation and care of individuals with inherited gastrointestinal cancer conditions. With the many recent advances made in genomic medicine and the potential impact on medical management, the articles in this issue disseminate new knowledge on the identification and management of individuals and families with a genetic susceptibility to the development of gastrointestinal cancers, including the genetic basis and cancer risks associated with inherited cancer syndromes and integrated familial cancer risk assessment; genetic testing approaches; and incorporating genetic risk counseling into routine medical care. The goal is to improve detection of GI cancer syndromes, understand related cancer risks, and optimize strategies for the prevention and early detection of cancers to minimize morbidity and mortality. Integrating genetic assessment into gastrointestinal cancer care is highly relevant across the cancer care spectrum and gastroenterologists will come away with the most current evidence to enhance and improve their clinical practice. - Provides in-depth, clinical reviews on Inherited GI Cancers: Identification, Management and the Role of Genetic Evaluation and Testing, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Contains 11 relevant, practice-oriented topics including Defining High-Risk Individuals for Pancreatic Cancer and the Role of Genetic Testing; Endoscopic Management and Surgical Consideration for FAP-Related Polyposis; Genetic Syndromes Associated with Gastric Cancer; Screening and Surgical Considerations in Hereditary Diffuse Gastric Cancer; and more.
Hereditary Gastric And Breast Cancer Syndrome
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Author : Giovanni Corso
language : en
Publisher: Springer Nature
Release Date : 2023-03-17
Hereditary Gastric And Breast Cancer Syndrome written by Giovanni Corso and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-17 with Medical categories.
In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
Genetic Polymorphism And Disease
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Author : Syed Sameer Aga
language : en
Publisher: CRC Press
Release Date : 2022-12-06
Genetic Polymorphism And Disease written by Syed Sameer Aga and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-06 with Science categories.
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics
Targeted Cancer Therapies From Small Molecules To Antibodies Volume Ii
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Author : Zhe-Sheng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-27
Targeted Cancer Therapies From Small Molecules To Antibodies Volume Ii written by Zhe-Sheng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-27 with Medical categories.
Phytochemicals Targeting Tumor Microenvironment In Gastrointestinal Cancers
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer Nature
Release Date : 2020-10-07
Phytochemicals Targeting Tumor Microenvironment In Gastrointestinal Cancers written by Ganji Purnachandra Nagaraju and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-07 with Medical categories.
Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
Targeting Myeloid Cells To Fight Cancer
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Author : Maija Hollmén
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-24
Targeting Myeloid Cells To Fight Cancer written by Maija Hollmén and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-24 with categories.
Exploring Oncolytic Virotherapy In Solid Tumor Treatment
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Author : Peng Qu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-26
Exploring Oncolytic Virotherapy In Solid Tumor Treatment written by Peng Qu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-26 with Medical categories.
Oncolytic virus therapy for solid tumor is an well-established concept as a promising tumor treatment strategy. Oncolytic viruses, either naturally occurring or genetically engineered, have the ability to replicate and destroy tumor cells while sparing normal cells. The lysis of tumor cells triggers potent antitumor responses and mediates tumor regression at distant sites not exposed to the virus. In 2015, the U.S. Food and Drug Administration (FDA) approved the first Oncolytic virus (OV) therapy for the treatment of melanoma lesions in the skin and lymph nodes. Despite these advancements, there are still unresolved issues regarding virus selection, dosage, and optimal administration route. The primary objective of this research topic is to monitor the latest developments in oncolytic virotherapy for solid tumors, including non-small cell lung cancer, gastric cancer, breast cancer, colorectal tumor, hepatic carcinoma, and others. The focus will be on the changes in both the immune microenvironment and immune cells induced by oncolytic virotherapy. Additionally, the research aims to discover novel oncolytic viruses or other combined therapies to enhance the safety and efficacy of oncolytic virotherapy.
Odze And Goldblum Surgical Pathology Of The Gi Tract Liver Biliary Tract And Pancreas E Book
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Author : Robert D. Odze
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-09-11
Odze And Goldblum Surgical Pathology Of The Gi Tract Liver Biliary Tract And Pancreas E Book written by Robert D. Odze and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-11 with Medical categories.
The updated edition of Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas is designed to act as a one-stop medical reference book for the entire gastrointestinal system, providing exhaustive coverage and equipping you with all of the necessary tools to make a comprehensive diagnostic workup. You'll access thousands of high-quality illustrations and eight brand-new chapters, so you can recognize and diagnose any pathological slide you encounter. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make a comprehensive diagnostic workup with data from ancillary techniques and molecular findings whenever appropriate. Effectively grasp complex topics and streamline decision-making by using extensive tables, graphs, and flowcharts. Avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Navigate the book quickly with a "road map" featured at the beginning of each chapter. Provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology, with access to the latest classification and staging systems available. Evaluate diagnostically challenging cases using diagnostic algorithms. Stay abreast of the latest advances with eight new chapters: Autoimmune Disorders of the GI Tract; Drug Induced Disorders of the GI Tract; Molecular Diagnostics of Tubal Gut Neoplasms; Molecular Diagnostics of the Gallbladder, Extrahepatic Biliary Tree, and Pancreatic Tumors; Tumors of the Ampulla; Molecular Diagnostics of Hepatocellular Neoplasms; Approach to the Liver Biopsy, and Approach to Gastrointestinal Tract Biopsies. Remain at the forefront of your field with coverage of new molecular and genetic markers in GI neoplasms; updated knowledge on liver and biliary tree pathology; and expanded information on tumors of the ampulla. Recognize and diagnose any tissue sample under the microscope with help from over 3000 high-quality color illustrations.
Targeted Therapies For Solid Tumors
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Author : Antonio Russo
language : en
Publisher: Humana Press
Release Date : 2015-03-11
Targeted Therapies For Solid Tumors written by Antonio Russo and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-11 with Medical categories.
This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.