Reviews On Biomarker Studies Of Metabolic And Metabolism Related Disorders
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Reviews On Biomarker Studies Of Metabolic And Metabolism Related Disorders
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Author : Paul C. Guest
language : en
Publisher: Springer
Release Date : 2019-03-27
Reviews On Biomarker Studies Of Metabolic And Metabolism Related Disorders written by Paul C. Guest and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-27 with Science categories.
The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.
Reviews On Biomarker Studies In Aging And Anti Aging Research
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Author : Paul C. Guest
language : en
Publisher: Springer Nature
Release Date : 2019-09-06
Reviews On Biomarker Studies In Aging And Anti Aging Research written by Paul C. Guest and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-06 with Science categories.
Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.
Neuroproteomics As A Tool For Understanding Schizophrenia
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Author : Daniel Martins-de-Souza
language : en
Publisher: Springer Nature
Release Date : 2022-08-05
Neuroproteomics As A Tool For Understanding Schizophrenia written by Daniel Martins-de-Souza and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-05 with Science categories.
Over the past decade, neuroproteomics has shed light on the molecular features of schizophrenia by depicting biological processes involved with its establishment, maintenance and treatment. These studies have also pointed to potential biomarkers applicable to diagnosis and medication monitoring. Edited by a leader in the field of neuroproteomics with contributions from subject experts, this new volume will address recent findings and compile evidence from difference perspectives—such as human samples, animal models, pluripotent stem cell-derived in vitro pre-clinical models—and provide findings to inform the development of innovative future treatment strategies. This volume will be useful for a broad audience of researchers and professionals, including biologists, neurologists, psychiatrists, analytical chemists, and pharmacists, among others.
Metabolic And Vascular Imaging Biomarkers For Brain Aging And Alzheimer S Disease
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Author : Ai-Ling Lin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-10
Metabolic And Vascular Imaging Biomarkers For Brain Aging And Alzheimer S Disease written by Ai-Ling Lin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with Science categories.
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis
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Author : George G. Harrigan
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-01-31
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis written by George G. Harrigan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-31 with Medical categories.
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Integrated Diagnostics And Biomarker Discovery In Endocrinology And Biomedical Sciences
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Author : Sijung Yun
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-02
Integrated Diagnostics And Biomarker Discovery In Endocrinology And Biomedical Sciences written by Sijung Yun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-02 with Medical categories.
Recent advancements and cost reduction in various omics technologies have provided us with a wealth of data at the molecular, cellular and organ levels. Other types of comprehensive data sets are also increasingly available at the individual, community and population levels. The integration of these different types of data are enabling multidisciplinary convergences in diagnostics and biomarker discovery in various biomedical fields to realize a more holistic, systems biology view of diseases. Such integrated approaches have also proven useful in the field of endocrinology, particularly in better understanding complex, heterogeneous diseases such as type 2 diabetes mellitus. For instance, researchers have combined genotyping data and RNA-sequencing data with glycomics and lipidomics to identify potential biomarkers in type 2 diabetes.
Reviews On New Drug Targets In Age Related Disorders
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Author : Paul C. Guest
language : en
Publisher: Springer Nature
Release Date : 2021-03-16
Reviews On New Drug Targets In Age Related Disorders written by Paul C. Guest and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-16 with Science categories.
Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.
Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research
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Author : Andras Szeitz
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-30
Metabolomics And Transcriptomics In Biomarker Discovery Mass Spectrometric Techniques In Volatilome Research written by Andras Szeitz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-30 with Science categories.
Metabolites are generated in part during catabolism when the consumed sources of energy undergo biotransformation, energy and metabolites are produced and the latter eliminated from the body. Volatile organic compounds (VOCs), semi-VOCs (SVOCs), etc., can be representatives of the metabolic processes, but also can be generated in pathologic conditions of organisms as signaling agents that transmit potential etiologic information on the disease states of the host. With recent advances in molecular biology and diagnostics, new forms of interdisciplinary science link VOC and SVOC production with genome, transcriptomic and proteomic data sets, and through biomarker discovery, translation and validation coupled with the latest advances in mass spectrometry, they contribute significantly to the emerging area called “volatilome” research. Volatilome research emerges in part from the awareness that organisms emit biomarker VOCs representative of their physiological state, stress conditions, etc., and on the mediating interactions between the host and the environment. For example, human and animal breath contains a vast number of VOCs that translate information about their health, and in case of plants, VOCs can be released in response to an external trigger, such as temperature or osmotic stress, herbivore perturbations, etc. Plant foliar VOCs contribute to potential application in crop stress response, defense, and enhanced biomass production which offers a renewable feedstock for sustainable energy and materials production within a biorefining context. Multi-omics is a valuable tool to investigate the processes involved in the fate of VOCs and their use as potential biomarkers in the inter-species microbiome utilizing the latest technologies in analytical chemistry, such as multidimensional gas or ultra-high performance liquid chromatography coupled with high resolution mass spectrometry.
Pet In The Evaluation Of Alzheimer S Disease And Related Disorders
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Author : Dan Silverman
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-14
Pet In The Evaluation Of Alzheimer S Disease And Related Disorders written by Dan Silverman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-14 with Medical categories.
Among all the clinical indications for which radiologists, nuclear medicine phy- cians, neurologists, neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders. This demand is driven by the sheer prevalence of those conditions, coupled with the fact that the differential diagnosis for causes of cognitive impairment is wide and often difficult to distinguish clinically. The conceptual framework by which evaluation and management of dementia is guided has evolved considerably during the last decade. Although we still are far from having ideal tests or dramatic cures for any of the established causes of dementia, our options have expanded with respect to both the diagnostic and the- peutic tools now available. In the first chapter of this book, the contribution and limitations of different elements of the clinical examination for diagnosis of cog- tive symptoms are described, and the roles of structural and functional neuroim- ing in the clinical workup are given context.
Novel Biomarkers In Alzheimer Rsquo S Disease
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Author : Chiara Villa
language : en
Publisher: MDPI
Release Date : 2021-02-05
Novel Biomarkers In Alzheimer Rsquo S Disease written by Chiara Villa and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-05 with Science categories.
Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.