Ricin Toxins

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Ricin Toxins

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Author : Nilgun E. Tumer
language : en
Publisher: MDPI
Release Date : 2020-12-14

Ricin Toxins written by Nilgun E. Tumer and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-14 with Science categories.

The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a by-product of castor oil, leading to exposure. Currently, there is no proven safe treatment for ricin intoxication. Ricin consists of an active A subunit (RTA) covalently linked to a cell binding B subunit (RTB). RTA depurinates a universally conserved adenine in the sarcin–ricin loop (SRL) of the large rRNA and inhibits protein synthesis. RTA-antibody complexes have been explored as immunotoxins against cancer cells. The articles published in this book address the history of ricin research, how ricin enters cells and traffics to the ribosome, how it inactivates ribosomes, how it induces inflammatory signaling pathways and programmed cell death, the design of therapies against ricin intoxication, and innovative assays for ricin detection.

Ricin And Shiga Toxins

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Author : Nicholas Mantis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-10

Ricin And Shiga Toxins written by Nicholas Mantis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-10 with Medical categories.

In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. The chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.

Genetically Engineered Toxins

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Author : Arthur Frankel
language : en
Publisher: CRC Press
Release Date : 2020-08-26

Genetically Engineered Toxins written by Arthur Frankel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.

Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.

Handbook Of Natural Toxins

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Author : R. F. Keeler
language : en
Publisher: CRC Press
Release Date : 1991-03-01

Handbook Of Natural Toxins written by R. F. Keeler and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-03-01 with Medical categories.

This volume describes some of the new research published since volume 1 of the series, Plant and fungal toxins , was published in 1983. A few chapters update topics previously treated, but most describe in depth the toxicologic and chemical aspects of other topics. Thus volumes 1 and 6 together prov

Chimeric Toxins

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Author : Haya Lorberboum-Galski
language : en
Publisher: CRC Press
Release Date : 2002-05-30

Chimeric Toxins written by Haya Lorberboum-Galski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-30 with Medical categories.

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati

Microbial Protein Toxins

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Author : Manfred Schmitt
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-12-10

Microbial Protein Toxins written by Manfred Schmitt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-10 with Science categories.

Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.

Trafficking Of Bacterial Toxins

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Author : Catharine B. Saelinger
language : en
Publisher: CRC Press
Release Date : 1989-12-21

Trafficking Of Bacterial Toxins written by Catharine B. Saelinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-12-21 with Science categories.

This work represents a compilation of studies on the entry into and subsequent processing of several bacterial and plant toxins in mammalian cells. Emphasis is placed on the close parallel of mammalian cell processing of toxic proteins and physiologically essential ligands. This easy-to-read book includes chapters which review the structures of the toxins. It compares and contrasts the trafficking of pseudomonas and diphtheria toxins. It also discusses anthrax toxin and the clostridial neurotoxins.

Immunotoxins

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Author : Arthur E. Frankel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Immunotoxins written by Arthur E. Frankel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Ribosome Inactivating Toxins

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Author : Julien Barbier
language : en
Publisher: MDPI
Release Date : 2019-01-17

Ribosome Inactivating Toxins written by Julien Barbier and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-17 with Medical categories.

This book is a printed edition of the Special Issue "Ribosome Inactivating Toxins" that was published in Toxins

Sittig S Handbook Of Toxic And Hazardous Chemicals And Carcinogens

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Author : Richard P. Pohanish
language : en
Publisher: William Andrew
Release Date : 2019-06-03

Sittig S Handbook Of Toxic And Hazardous Chemicals And Carcinogens written by Richard P. Pohanish and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-03 with Medical categories.

Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Seventh Edition, has proven to be a reliable, accessible, must-have reference on hazardous materials for over thirty years. This updated and revised seventh edition is the most comprehensive listing of the hazardous chemicals commonly used, transported, and regulated in industry and the workplace. Information is the most vital resource anyone can have when dealing with potential hazardous substance accidents, spillages, fires, or acts of terror. It is also essential for the safe day-to-day operation of chemical processes and environmental protection. Sittig's Handbook provides extensive data for over 2,200 chemicals in a uniform format, enabling fast and accurate decisions in any situation. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. This new edition contains expanded and reviewed information for each chemical listed (including chemicals classified as WMD) and has been updated to keep pace with world events, standards, and regulations. This seventh edition includes over 100 new records, and every single record has been checked and updated as necessary. - Enables readers to quickly and reliably find the chemical they are looking for, with a full range of synonyms for each chemical, including trade names and CAS index - Features relevant data for the US and EU included throughout, along with the essential chemical hazard information applicable worldwide - Provides a trusted source of information for first-line responders (emergency services), industry, logistics companies, scientists, and environmental protection organizations - Contains expanded information for each chemical listed (including chemicals classified as WMD) and has been updated to keep pace with world events, standards, and regulations