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Rna Modification And Non Coding Rnas In Human Disease


Rna Modification And Non Coding Rnas In Human Disease
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Rna Modification And Non Coding Rnas In Human Disease


Rna Modification And Non Coding Rnas In Human Disease
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Author : Jing Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-14

Rna Modification And Non Coding Rnas In Human Disease written by Jing Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-14 with Science categories.




Long Non Coding Rnas In Cancer


Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2021-06-24

Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.


This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.



Long Non Coding Rnas In Human Disease


Long Non Coding Rnas In Human Disease
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Author : Kevin V. Morris
language : en
Publisher: Springer
Release Date : 2016-04-13

Long Non Coding Rnas In Human Disease written by Kevin V. Morris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-13 with Medical categories.


This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.



Non Coding Rnas And Human Diseases


Non Coding Rnas And Human Diseases
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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08

Non Coding Rnas And Human Diseases written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.




Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease


Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease
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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06

Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Science categories.


Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides rarely translatable into protein, which distinguishes them from small non-coding RNAs (sncRNAs) such as miRNAs, siRNAs, piRNAs, snoRNAs exRNAs, (scaRNAs). Long intervening/intergenic noncoding RNAs (lincRNAs) refer to lncRNA non-overlapped to protein-coding genes. In terms of abundance and specificity, ~30,000 lncRNAs have been identified in human tissues with ~ 10- fold lower abundance than mRNA. Near 80% of lncRNAs show tissue-specific features, in contrast to only less than 20% of mRNAs. In addition to tissue specificity, lncRNAs are also characterized by having significantly higher developmental stage specificity. Of the identified lncRNAs, although only a very small proportion have been validated to be biologically relevant, the emerging evidence has confirmed important regulatory functions at levels of transcription, post transcription, and epigenetic control. Physiologically, lncRNAs are involved in growth, development, reproduction, aging, and pathogenesis of disease initiation and progression, such as neurological disorders and cancers.



Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease


Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease
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Author : Amanda Salviano-Silva
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-11

Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease written by Amanda Salviano-Silva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-11 with Science categories.




Rna Therapeutics In Human Diseases


Rna Therapeutics In Human Diseases
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Author : Phei Er Saw
language : en
Publisher: Springer Nature
Release Date : 2025-06-09

Rna Therapeutics In Human Diseases written by Phei Er Saw and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-09 with Medical categories.


"RNA Therapeutics in Human Diseases" is a comprehensive guide to the rapidly evolving field of RNA-based therapies. Divided into three parts, the book covers RNA biology, technical advancements in RNA therapeutics, and their clinical applications. It explores the roles of various RNAs (including mRNA, miRNA, lncRNA, and circRNA) in disease mechanisms and therapeutic strategies, as well as cutting-edge techniques like RNA sequencing, RNA nanotechnology, and AI-driven drug design. Readers will gain in-depth insights into the latest RNA research and its potential to transform genetic medicine, providing both foundational knowledge and practical perspectives for researchers, clinicians, and policymakers.



Long Noncoding Rnas In Plants


Long Noncoding Rnas In Plants
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Author : Santosh Kumar Upadhyay
language : en
Publisher: Academic Press
Release Date : 2020-11-13

Long Noncoding Rnas In Plants written by Santosh Kumar Upadhyay and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-13 with Science categories.


The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. - Includes the latest advances and research in long noncoding RNAs in plants - Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops - Focuses on the application and uses of long noncoding RNAs



Regulation Of Gene Expression By Small Rnas


Regulation Of Gene Expression By Small Rnas
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Author : Rajesh K. Gaur
language : en
Publisher: CRC Press
Release Date : 2009-04-27

Regulation Of Gene Expression By Small Rnas written by Rajesh K. Gaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-27 with Science categories.


New Findings Revolutionize Concepts of Gene FunctionEndogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 p



Role Of Rna Modification In Disease


Role Of Rna Modification In Disease
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Author : Emanuele Buratti
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-03

Role Of Rna Modification In Disease written by Emanuele Buratti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with categories.