Single Molecule Fluorescence Studies Of Protein Folding And Molecular Chaperones
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Single Molecule Fluorescence Studies Of Protein Folding And Molecular Chaperones
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Author : Martin Sikor
language : de
Publisher:
Release Date : 2011
Single Molecule Fluorescence Studies Of Protein Folding And Molecular Chaperones written by Martin Sikor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Single Molecule Fluorescence Spectroscopy Of The Folding Of A Repeat Protein
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Author : Sharona Cohen
language : en
Publisher: Springer
Release Date : 2015-10-17
Single Molecule Fluorescence Spectroscopy Of The Folding Of A Repeat Protein written by Sharona Cohen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-17 with Science categories.
In this thesis single-molecule fluorescence resonance energy transfer (FRET) spectroscopy was used to study the folding of a protein that belongs to the large and important family of repeat proteins. Cohen shows that the dynamics of the expanded conformations is likely to be very fast, suggesting a spring-like motion of the whole chain. The findings shed new light on the elasticity of structure in repeat proteins, which is related to their function in binding multiple and disparate partners. This concise research summary provides useful insights for students beginning a PhD in this or a related area, and researchers entering this field.
Observing Protein Dynamics And Conformational Changes By Ensemble And Single Molecule Fluorescence Spectroscopy
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Author : So Yeon Kim
language : en
Publisher:
Release Date : 2008
Observing Protein Dynamics And Conformational Changes By Ensemble And Single Molecule Fluorescence Spectroscopy written by So Yeon Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Biophysics Of Molecular Chaperones
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Author : Sebastian Hiller
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-11-01
Biophysics Of Molecular Chaperones written by Sebastian Hiller and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.
Protein Folding Misfolding And Aggregation
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Author : Victor Muñoz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008-06-24
Protein Folding Misfolding And Aggregation written by Victor Muñoz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-24 with Science categories.
Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses.
The Molecular Chaperones Interaction Networks In Protein Folding And Degradation
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Author : Walid A. Houry
language : en
Publisher: Springer
Release Date : 2014-09-01
The Molecular Chaperones Interaction Networks In Protein Folding And Degradation written by Walid A. Houry and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with Science categories.
Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective.
Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins
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Author : Mario D. Galigniana
language : en
Publisher: Bentham Science Publishers
Release Date : 2018-04-26
Role Of Molecular Chaperones In Structural Folding Biological Functions And Drug Interactions Of Client Proteins written by Mario D. Galigniana and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-26 with Science categories.
The book provides an updated panorama of the functional relevance of molecular chaperones in the proper folding of client factors, protein-protein interactions, the regulation of key biological functions, the development of ligand-based structural complexes and the consequent pharmacological or biotechnological applications of these processes. The involvement of molecular chaperones in several processes ranging from regulation of transcription factors and protein-protein interactions in bacteria to proteostasis, signaling pathways and cancer are also addressed. The book is an essential consulting tool for researchers, working professionals in academia or industry, and students of all levels who wish to obtain the most relevant and updated information currently available about protein folding and chaperones.
Protein Folding
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Author : Jeffrey L. Cleland
language : en
Publisher: Wiley-VCH
Release Date : 1993-06-23
Protein Folding written by Jeffrey L. Cleland and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-23 with Science categories.
Covers the most recent advances in the field of protein folding and its impact on future technologies. Reviews in vivo aspects such as mechanisms of inclusion body formation and molecular chaperones, and includes highlights of Jonathan King's work at MIT. In vitro aspects examined include methods of protein folding, recovery of commercial protein products, and genetic approaches to understanding and solving protein folding problems. Written by leading scientists in the field, the volume provides a linkage between fundamental academic research and industrial applications of protein folding technology.
Molecular Chaperones
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Author : Sophie Jackson
language : en
Publisher: Springer
Release Date : 2012-12-15
Molecular Chaperones written by Sophie Jackson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-15 with Science categories.
Assisting Oxidative Protein Folding: How Do Protein Disulphide-Isomerases Couple Conformational and Chemical Processes in Protein Folding?, by A. Katrine Wallis and Robert B. Freedman Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, by Cordelia Schiene-Fischer, Tobias Aumüller and Gunter Fischer Small Heat-Shock Proteins: Paramedics of the Cell, by Gillian R. Hilton, Hadi Lioe, Florian Stengel, Andrew J. Baldwin und Justin L. P. Benesch Allostery in the Hsp70 Chaperone Proteins, by Erik R. P. Zuiderweg, Eric B. Bertelsen, Aikaterini Rousaki, Matthias P. Mayer, Jason E. Gestwicki and Atta Ahmad Hsp90: Structure and Function, by Sophie E. Jackson Extracellular Chaperones, by Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd and Mark R. Wilson
Single Molecule Studies Of Nucleic Acids And Their Proteins
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Author : David Bensimon
language : en
Publisher: Oxford University Press
Release Date : 2018-11-30
Single Molecule Studies Of Nucleic Acids And Their Proteins written by David Bensimon and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-30 with Science categories.
This book provides the basis for understanding the elastic properties of nucleic acids (DNA, RNA), the methods used to manipulate them (e.g. optical, magnetic and acoustic tweezers and traps), and how to observe their interactions with proteins (e.g. fluorescence microscopy, FCS, FRET, etc.). It then exemplifies the use of these various methods in the study of three families of DNA enzymes: polymerases, helicases and topoisomerases. The book aims not to be exhaustive, but rather to stimulate the imagination of readers in the application of these single molecule approaches to the study of DNA/RNA and their interactions.