Tamoxifen And Breast Cancer
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Tamoxifen And Breast Cancer
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Author : Michael W. DeGregorio
language : en
Publisher: Yale University Press
Release Date : 1999-01-01
Tamoxifen And Breast Cancer written by Michael W. DeGregorio and has been published by Yale University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Medical categories.
A discussion of the diagnosis of breast cancer and the risks, benefits and limitations of treatment alternatives, particularly tamoxifen. This edition contains information on developments in the use of tamoxifen, especially in the results of the Breast Cancer Prevention Trial.
Tamoxifen
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Author : Philipp Y. Maximov
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-23
Tamoxifen written by Philipp Y. Maximov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-23 with Medical categories.
Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
Tamoxifen And Breast Cancer
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Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
language : en
Publisher:
Release Date : 1998
Tamoxifen And Breast Cancer written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Long Term Tamoxifen Treatment For Breast Cancer
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Author : Virgil Craig Jordan
language : en
Publisher: Univ of Wisconsin Press
Release Date : 1994
Long Term Tamoxifen Treatment For Breast Cancer written by Virgil Craig Jordan and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Breast categories.
During the past twenty years tamoxifen has become the most widely prescribed and most successful drug used in the treatment of breast cancer. In this volume, editor V. Craig Jordan provides articles that trace the development, pharmacology, and clinical research surrounding this drug which, by the year 2000, could be used to treat as many as one million women annually. Drawing from research conducted by specialists in the United States, the United Kingdom, and Italy, the series of articles describes the clinical testing of tamoxifen, highlighting the benefits. Studies show that tamoxifen lowers cholesterol and can potentially protect women against osteoporosis and fatal coronary heart disease. Equally important is a discussion of side effects and possible drug interactions and how these issues relate to patient concerns. An investigation of the development of a new class of drugs for use after tamoxifen fails provides valuable insight into future treatments, as the contributers consider possible resistance to tamoxifen. This volume provides invaluable information for physicians and surgeons who care for patients with breast cancer and for women interested in exploring this therapeutic dimension.
The Role Of Tamoxifen In Breast Cancer
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Author : Stefano Iacobelli
language : en
Publisher:
Release Date : 1982
The Role Of Tamoxifen In Breast Cancer written by Stefano Iacobelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Breast categories.
Tamoxifen
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Author : Virgil Craig Jordan
language : en
Publisher: Oncology Group
Release Date : 1996
Tamoxifen written by Virgil Craig Jordan and has been published by Oncology Group this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Health & Fitness categories.
Tamoxifen
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Author : John A. Kellen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Tamoxifen written by John A. Kellen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.
The Role Of Tamoxifen In Breast Cancer
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Author : Stefano Iacobelli
language : en
Publisher:
Release Date : 1982-01-01
The Role Of Tamoxifen In Breast Cancer written by Stefano Iacobelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-01-01 with categories.
Tamoxifen Concepts And Cancer
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Author : Ramon Andrade de Mello
language : en
Publisher: Nova Biomedical Books
Release Date : 2013
Tamoxifen Concepts And Cancer written by Ramon Andrade de Mello and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Breast categories.
Tamoxifen was first approved in 1977 and up to now remains a noteworthy therapeutic weapon to treat mainly breast cancer. However, further considerations exist regarding the tamoxifen profile. This book discusses recent research and future perspectives in the tamoxifen field. The topics discussed include tamoxifen pharmacokinetics, pharmacodynamics, adverse effects, clinical indications, therapeutic drug monitoring, autophagy mechanisms, tamoxifen topical formulation and breast cancer risk prevention, the use of tamoxifen in an oestrogen-independent manner for various neoplasms (Hepatocellular carcinoma, renal cell carcinoma, high grade glioma), mechanisms of resistance, potential role of CYP2D6, tamoxifen and antidepressants interaction in a psychiatric view, obesity influence in tamoxifen treatment, electrical pulse-mediated tamoxifen delivery, and tamoxifen in melanoma treatment.
Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer
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Author : Mark Robson
language : en
Publisher:
Release Date : 2002
Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer written by Mark Robson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Women with breast cancer arising as a consequence of germline mutations in BRCA1 or BRCA2 are at significant risk of contralateral breast cancer (CBC). Examination of factors influencing contralateral risk will provide insight into prevention strategies for unaffected women with BRCA mutations. A combined analysis performed with the JGH indicates tamoxifen may reduce CBC risk by 53% (attached). To evaluate CBC risk factors, the funded study is assessing the impact of tamoxifen and radiotherapy on CBC risk. In the present funding period, in accordance with the Statement of Work, continued review of clinical records was performed, with identification of pathology blocks that will be cut to provide the samples for genotyping. Medical records from 1990 and 1991 were not reliably retrievable, leading us to expand the cohort eligibility dates to 199E. As of this report, we have reviewed 692 records in this interval, of whom 453 are eligible and for whom data has been entered. Data cleaning is in process and acquisition of tissue samples will begin shortly, followed by genotyping after anonymization. Combining these data with our original cohort of 329 cancers in 305 patients (JNCI 1999), we will have achieved 78% of our accrual goal of 1000 cases.