Technical Aspects Of Focal Therapy In Localized Prostate Cancer
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Technical Aspects Of Focal Therapy In Localized Prostate Cancer
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Author : Eric Barret
language : en
Publisher: Springer
Release Date : 2015-01-29
Technical Aspects Of Focal Therapy In Localized Prostate Cancer written by Eric Barret and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-29 with Medical categories.
Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.
Focal Therapy Of Prostate Cancer
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Author : Stefan Thüroff
language : en
Publisher: Springer
Release Date : 2015-03-20
Focal Therapy Of Prostate Cancer written by Stefan Thüroff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-20 with Medical categories.
This book provides a 2015 state of the art update on the hot topic of focal prostate cancer therapy, which offers a means of preserving the prostate and avoiding major side-effects associated with conventional treatment strategies. In so doing, focal therapy meets the desire of many patients, especially those with low-risk disease, to avoid or postpone radical therapies in order to preserve quality of life. A wide range of aspects are covered, including the role of imaging-guided targeted biopsies, the pros and cons of surveillance in comparison with focal therapy, focal hemiablation and focal salvage therapy, multifocal therapies, focal cryotherapy. The potential role of various new diagnostic technologies as well as specific therapeutic devices as "Focal.One" robotic high-intensity focused ultrasound are explained. The authors are all international experts who are long-term proponents of non-invasive treatment of prostate cancer. "Focal Therapy of Prostate Cancer" will be an invaluable source of information for urologists, oncologists, radiation oncologists, and general practitioners, and also for patients wishing to learn more about this new treatment option.
Focal Therapy In Prostate Cancer
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Author : Hashim Uddin Ahmed
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-19
Focal Therapy In Prostate Cancer written by Hashim Uddin Ahmed and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-19 with Medical categories.
This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
Imaging And Focal Therapy Of Early Prostate Cancer
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Author : Thomas J. Polascik
language : en
Publisher: Springer
Release Date : 2017-02-22
Imaging And Focal Therapy Of Early Prostate Cancer written by Thomas J. Polascik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-22 with Medical categories.
This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.
Handbook Of Focal Therapy For Prostate And Renal Cancer
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Author : Truls Bjerklund Johansen
language : en
Publisher: JP Medical Ltd
Release Date : 2016-09-06
Handbook Of Focal Therapy For Prostate And Renal Cancer written by Truls Bjerklund Johansen and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-06 with Medical categories.
Provides a comprehensive, timely review of targeted ablation methods to treat prostate and renal cancers. It describes the most effective techniques in current practice, with discussion of the selection criteria, ablation technologies and their limitations, and advice on the management of common side effects.
Active Surveillance For Localized Prostate Cancer
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Author : Laurence Klotz
language : en
Publisher: Humana Press
Release Date : 2017-09-29
Active Surveillance For Localized Prostate Cancer written by Laurence Klotz and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-29 with Medical categories.
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
New Technology And Techniques For Needle Based Magnetic Resonance Image Guided Prostate Focal Therapy
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Author : Jeremy J. Cepek
language : en
Publisher:
Release Date : 2013
New Technology And Techniques For Needle Based Magnetic Resonance Image Guided Prostate Focal Therapy written by Jeremy J. Cepek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The most common diagnosis of prostate cancer is that of localized disease, and unfortunately the optimal type of treatment for these men is not yet certain. Magnetic resonance image (MRI)-guided focal laser ablation (FLA) therapy is a promising potential treatment option for select men with localized prostate cancer, and may result in fewer side effects than whole-gland therapies, while still achieving oncologic control. The objective of this thesis was to develop methods of accurately guiding needles to the prostate within the bore of a clinical MRI scanner for MRI-guided FLA therapy. To achieve this goal, a mechatronic needle guidance system was developed. The system enables precise targeting of prostate tumours through angulated trajectories and insertion of needles with the patient in the bore of a clinical MRI scanner. After confirming sufficient accuracy in phantoms, and good MRI-compatibility, the system was used to guide needles for MRI-guided FLA therapy in eight patients. Results from this case series demonstrated an improvement in needle guidance time and ease of needle delivery compared to conventional approaches. Methods of more reliable treatment planning were sought, leading to the development of a systematic treatment planning method, and Monte Carlo simulations of needle placement uncertainty. The result was an estimate of the maximum size of focal target that can be confidently ablated using the mechatronic needle guidance system, leading to better guidelines for patient eligibility. These results also quantified the benefit that could be gained with improved techniques for needle guidance.
Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy
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Author : Alan Martin Priester
language : en
Publisher:
Release Date : 2017
Correlation Of Imaging And Pathology To Advance The Study Of Prostate Cancer Focal Therapy written by Alan Martin Priester and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Prostate cancer, a disease diagnosed in approximately 220,000 men in the U.S. annually, has historically been treated through extirpation of the entire gland. Unfortunately, whole-gland interventions exact a heavy toll, often resulting in incontinence and impotence. One proposed alternative is focal therapy, wherein MR-visible tumor foci are treated locally while sparing the majority of healthy tissue. This approach has great potential to deliver curative treatment while reducing costs and risks. In order to demonstrate the safety, efficacy, and practicality of focal therapy, several key questions remain: 1. How reliably can tumor location be distinguished? 2. What treatment margins are necessary? 3. Can treatment be delivered safely in a clinic setting? This thesis presents a concerted effort to answer these questions, guided by the central hypothesis that focal therapy can be made safe and effective by registering MRI with ultrasound, pathology, and thermal data. To this end, we characterized and clinically implemented a means of accurately correlating MRI with histopathology. We discovered that many tumors extend far beyond the confines of MR-visibility, and the average tumor was three times its predicted volume. Isotropic margins in excess of 1 cm would have been necessary to treat the majority of focal therapy eligible men. However, by registering tracked biopsy data with MRI, we demonstrated that patient-specific treatment margins can greatly improve cancer prediction. We performed clinical trials investigating the safety of focal laser ablation (FLA) of prostate cancer, a modality wherein an interstitial laser delivers thermal energy and induces coagulative necrosis. Through analysis of MRI thermometry data, we found that thermal damage could be predicted with less than 15% volumetric error (0.5 cc). In a second clinical trial, FLA was performed under the guidance of MRI-US fusion imaging. This trial demonstrated that focal therapy could be performed safely, in a clinic setting, and without risk of incontinence or impotence. Furthermore, clinically significant cancer was eliminated from 60% of men, demonstrating the potential efficacy of localized treatment. Future work is necessary to refine all aspects of prostate focal therapy. However, this thesis lays a foundation for safe and effective treatment of localized prostate cancer.
Multidisciplinary Management Of Prostate Cancer
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Author : Vincenzo Gentile
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-04-11
Multidisciplinary Management Of Prostate Cancer written by Vincenzo Gentile and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-11 with Medical categories.
Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer.
Active Surveillance For Localized Prostate Cancer
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Author : Laurence Klotz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-21
Active Surveillance For Localized Prostate Cancer written by Laurence Klotz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-21 with Medical categories.
Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.