The Nociceptive Membrane
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The Nociceptive Membrane
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-09-21
The Nociceptive Membrane written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-21 with Science categories.
Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.
Ion Channels Of Nociception
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Author : Rashid Giniatullin
language : en
Publisher: MDPI
Release Date : 2020-12-02
Ion Channels Of Nociception written by Rashid Giniatullin and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
The Special Issue “Ion Channels of Nociception” contains 13 articles united by a focus on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes; nociceptive roles of P2X3, ASIC, Piezo and TRP channels; pain control through GPCRs and pharmacological agents; and nonpharmacological treatment with electroacupuncture.
The Perplexing Physiology Of The Nociceptive System
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Author : Istvan Nagy
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-11
The Perplexing Physiology Of The Nociceptive System written by Istvan Nagy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-11 with Science categories.
Impacts that threaten or indeed compromise the integrity of tissues trigger the development of a defence response, which through the activity of the nociceptive system includes pain. If the noxious impact does not induce tissue damage, the pain, called “nociceptive” pain, ceases within seconds after the impact is withdrawn. In contrast, if tissue damage does occur, a pain experience that usually persists until the injury is resolved and includes two major pathological sensory experiences, hypersensitivity to heat stimuli (i.e. heat hyperalgesia) and/or hypersensitivity to mechanical stimuli (i.e. mechanical allodynia) develop. The cellular and molecular mechanisms underlying the development of nociceptive pain are fairly well understood. Our understanding of the development of pain associated with tissue injury has also significantly improved in the last decades. Hence, two fundamental mechanisms, interactions between the nervous and immune systems both within and without the central nervous system and sensitization that is a use-dependent increase in the sensitivity and activity of neurons involved in nociceptive processing have been identified being pivotal for the development of tissue injury-associated pain. However, important details of the cellular and molecular mechanisms, which account for the development of the pathological sensory experiences and those experiences becoming persistent, still await elucidation.
Neurobiology Of Nociceptors
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Author : C. Belmonte
language : en
Publisher:
Release Date : 1996
Neurobiology Of Nociceptors written by C. Belmonte and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
This is the first comprehensive review of all aspects of nociceptor fu nction, including the structure of nociceptor endings, neurochemistry, and evolutionary considerations. It deals with the functional propert ies of nociceptors innervating different organs and the biophysical me chanisms underpinning the transduction process in nociceptors. Section s cover the modification of nociceptor function by nerve injury and re generation, as well as its physiopathology. This is an essential refer ence for researchers in neuroscience and pharmacology, and clinicians working in pain management.
Cellular And Molecular Mechanisms For The Modulation Of Nociceptive Transmission In The Peripheral And Central Nervous Systems
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Author : Eiichi Kumamoto
language : en
Publisher:
Release Date : 2007-01-01
Cellular And Molecular Mechanisms For The Modulation Of Nociceptive Transmission In The Peripheral And Central Nervous Systems written by Eiichi Kumamoto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Cellular control mechanisms categories.
Nociceptive information from the periphery is transmitted through primary-afferent fibers to spinal dorsal horn, particularly substantia gelatinosa (lamina II) neurons. This information flows to the thalamus and then to the primary sensory area of the cerebral cortex, eliciting nociceptive sensation. In addition to the pathway responsible for the sensory aspect of pain, there is another pathway involved in the emotional aspect of pain that affects the pain perception. Such a nociceptive transmission is modulated by a variety of endogenous and exogenous chemical substances in the peripheral and central nervous systems. This book entitled as Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems gives some examples of such a modulation of nociceptive transmission that was revealed from morphological, electrophysiological and behavioral studies. Chapter 1 describes a detail of the structure of synapses which are formed between primary-afferent fibers and substantia gelatinosa neurons being thought to play an important role in regulating the nociceptive transmission. Chapter 2 makes a general survey of the involvement of TRP channels in detecting nociceptive stimuli. Chapter 3 raises a question regarding the well-known modulatory role of prostaglandin E2 on tetrodotoxin-resistant Na+ channels expressed in primary-afferent neurons in inflammatory hyperalgesia. Although ATP is well-known to act as a chemical messenger to transfer sensory information, Chapters 4 and 5 mention that the activation of ionotropic P2X receptors for ATP participates in the modulation of nociceptive transmission at the peripheral and central nervous systems. Chapter 6 demonstrates that m-opioid receptor mediated membrane hyperpolarization and reduction of L-glutamate release from nerve terminals in the substantia gelatinosa play a pivotal role in the antinociceptive effect of opioids at the spinal dorsal horn level. Chapter 7 describes how phospholipase A2 activation affects glutamatergic excitatory and (GABAergic and/or glycinergic) inhibitory transmission in the substantia gelatinosa by using melittin as a tool to activate this enzyme. It has been pointed out in Chapter 8 that a down-regulation of inhibitory neurotransmitters (GABA and glycine) and their receptors, or a cell death of inhibitory interneurons in the substantia gelatinosa may result in neuropathic pain. Chapter 9 demonstrates that subcutaneous injection of bee venom, particularly melittin, in rats would cause a series of pathophysiological processes of pain which can mimic multiple manifestations of clinical pathological pain. Although pain contains not only sensory but also emotional responses, Chapters 10 and 11 mention that the midbrain and anterior cingulate cortex play an important role in the emotional aspect of pain. In summary, this book is relevant for graduate students and researchers who are interested in the modulation of nociceptive transmission at the cellular and molecular level. I express cordial thank to Dr. S.G. Pandalai for kindly giving me an opportunity to edit this book and Dr. T. Fujita for her great help in preparation of the final version of all the manuscripts and figures.
Pain Modulation
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Author : Howard L. Fields
language : en
Publisher: Elsevier Publishing Company
Release Date : 1988-01-01
Pain Modulation written by Howard L. Fields and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Medical categories.
This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Fundamentals Of Anaesthesia
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Author : Colin Pinnock
language : en
Publisher: Cambridge University Press
Release Date : 2002-12
Fundamentals Of Anaesthesia written by Colin Pinnock and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12 with Medical categories.
The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
The Genetics Of Pain
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Author : Jeffrey Steven Mogil
language : en
Publisher: Progress in Pain Research and
Release Date : 2004
The Genetics Of Pain written by Jeffrey Steven Mogil and has been published by Progress in Pain Research and this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Translational Pain Research
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Author : Lawrence Kruger
language : en
Publisher: CRC Press
Release Date : 2009-11-24
Translational Pain Research written by Lawrence Kruger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with Health & Fitness categories.
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
The Essence Of Analgesia And Analgesics
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Author : Raymond S. Sinatra
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-14
The Essence Of Analgesia And Analgesics written by Raymond S. Sinatra and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-14 with Medical categories.
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.