The P2x7 Receptor
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The P2x7 Receptor
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Author : Annette Nicke
language : en
Publisher: Springer Nature
Release Date : 2022-07-01
The P2x7 Receptor written by Annette Nicke and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-01 with Science categories.
This detailed volume covers diverse aspects of P2X7 receptor analysis, ranging from its molecular structure to related pharmacological and immunological tools, via its analysis in heterologous expression systems as well as assays using primary cells and whole animal models. After three introductory chapters that focus on its structure, ligands, and physiological functions, the book details the generation of antibody and nanobody tools for P2X7 receptors, provides protocols for the analysis of expressed P2X7 receptors with a focus on their electrophysiological analysis, as well as protocols for the investigation of P2X7 down-stream signaling in immune cells by flow cytometry. Mouse models and procedures suited to investigate P2X7-mediated effects in other primary cells and in vivo are also explained. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The P2X7 Receptor: Methods and Protocols is a valuable reference not only for the growing community fascinated by this unusual ion channel but also for a broad readership interested in ion channels or purinergic receptors.
P2x7 As Common Therapeutic Target In Brain Diseases
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Author : Tobias Engel
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-29
P2x7 As Common Therapeutic Target In Brain Diseases written by Tobias Engel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives
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Author : Rosa Gomez-Villafuertes
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Emerging Mechanisms In Purinergic Signaling From Cell Biology To Therapeutic Perspectives written by Rosa Gomez-Villafuertes and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.
Role Of The P2x7 Nucleotide Receptor In Lipopolysaccharide Stimulated Macrophage Activation
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Author : Philip L. Fisette
language : en
Publisher:
Release Date : 1999
Role Of The P2x7 Nucleotide Receptor In Lipopolysaccharide Stimulated Macrophage Activation written by Philip L. Fisette and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Purinergic Pharmacology
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Author : Francisco Ciruela
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Purinergic Pharmacology written by Francisco Ciruela and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Purinergic Signaling In Health And Disease
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Author : Eric Boué-Grabot
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-13
Purinergic Signaling In Health And Disease written by Eric Boué-Grabot and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with categories.
Role Of The P2rx7 Nucleotide Receptor In Transcriptional Activation Of Monocytic Cells
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Author : Monica Lynn Gavala
language : en
Publisher:
Release Date : 2008
Role Of The P2rx7 Nucleotide Receptor In Transcriptional Activation Of Monocytic Cells written by Monica Lynn Gavala and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Cystogenesis
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Author : Jong Hoon Park
language : en
Publisher: Springer
Release Date : 2016-10-12
Cystogenesis written by Jong Hoon Park and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Medical categories.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Purinergic Signaling And Inflammation
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Author : Davide Ferrari
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-14
Purinergic Signaling And Inflammation written by Davide Ferrari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
Astrocytes And Epilepsy
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Author : Jacqueline A. Hubbard
language : en
Publisher: Academic Press
Release Date : 2016-07-05
Astrocytes And Epilepsy written by Jacqueline A. Hubbard and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-05 with Medical categories.
Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation