The T Cell Receptor Factsbook
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The T Cell Receptor Factsbook
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Author : Marie-Paule Lefranc
language : en
Publisher: Elsevier
Release Date : 2001-07-13
The T Cell Receptor Factsbook written by Marie-Paule Lefranc and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-13 with Medical categories.
The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.
The T Cell Receptors
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Author : Tak W. Mak
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The T Cell Receptors written by Tak W. Mak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
The Antigen T Cell Receptor
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Author : Jorge R. Oksenberg
language : en
Publisher: Kluwer Academic Publishers
Release Date : 1997
The Antigen T Cell Receptor written by Jorge R. Oksenberg and has been published by Kluwer Academic Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with T cells categories.
T Lymphocytes And Their Receptors In Immunologic Recognition
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Author : Boris Davydovich Brondz
language : en
Publisher: CRC Press
Release Date : 1988
T Lymphocytes And Their Receptors In Immunologic Recognition written by Boris Davydovich Brondz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
The Hla Factsbook
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Author : Steven G.E. Marsh
language : en
Publisher: Elsevier
Release Date : 1999-12-13
The Hla Factsbook written by Steven G.E. Marsh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-13 with Medical categories.
The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references
Antigen Specific T Cell Receptors And Factors
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Author :
language : en
Publisher:
Release Date : 1987
Antigen Specific T Cell Receptors And Factors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Antigens categories.
The Immunoglobulin Factsbook
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Author : Marie-Paule Lefranc
language : en
Publisher: Academic Press
Release Date : 2001-05-23
The Immunoglobulin Factsbook written by Marie-Paule Lefranc and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-23 with Medical categories.
The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
Immunoinformatics
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Author : Christian Schönbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-21
Immunoinformatics written by Christian Schönbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-21 with Medical categories.
In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.
Analyzing T Cell Responses
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Author : Dirk Nagorsen
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-16
Analyzing T Cell Responses written by Dirk Nagorsen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Medical categories.
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated patients but are not quantitative. In contrast, novel assays such as enzyme-linked immunospot (ELISPOT) assay, intracellular cytokine assay and tetramer assay can quantitate the frequency of antigen-specific T cells. Of these, the ELISPOT assay has the 5 lowest detection limit with 1/10 peripheral blood mononuclear cells (PBMC) and has been determined to be one of the most useful assays to evaluate immune response to cancer vaccines (4). However, the IFN-? ELISPOT assay is not an exclusive measure of cytotoxic T-lymphocyte (CTL) activity as non-cytotoxic cells can also secrete IFN-?. Additionally, CTL with lytic activity do not always secrete IFN-? (5). A more relevant approach to assess functional activity of cytotoxic lymphocytes would be to measure the secretion of molecules that are associated with lytic activity. One of the major mechanisms of cell-mediated cytotoxicity involves exocytosis of cytoplasmic granules from the effector toward the target cell.
The Leucocyte Antigen Factsbook
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Author : A. Neil Barclay
language : en
Publisher: Elsevier
Release Date : 1997-06-22
The Leucocyte Antigen Factsbook written by A. Neil Barclay and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-22 with Medical categories.
A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists. Key Features* Completely up-to-date* Revised and expanded to include over 70 new entries* More than 200 entries in total, plus additional introductory material* New structural data* New nomenclature for CD and related molecules covered