The T Cell Receptors
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The T Cell Receptors
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Author : Tak W. Mak
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The T Cell Receptors written by Tak W. Mak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
The T Cell Receptor Factsbook
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Author : Marie-Paule Lefranc
language : en
Publisher: Elsevier
Release Date : 2001-07-13
The T Cell Receptor Factsbook written by Marie-Paule Lefranc and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-13 with Medical categories.
The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.
Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Antigen Specific T Cell Receptors And Factors
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Author :
language : en
Publisher:
Release Date : 1987
Antigen Specific T Cell Receptors And Factors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Antigens categories.
T Cell Receptors
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Author : Owen Simpson Bell
language : en
Publisher: Oxford University Press, USA
Release Date : 1995
T Cell Receptors written by Owen Simpson Bell and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Immunogenetics. categories.
"T cell receptors is a comprehensive treatise on the T cell receptor. It deals with the TCR protein, its functional interactions with the signal transduction machinery of the T cell and with the structure and organization of the TCR genes. It is the only comprehensive volume on the TCR and is written by leaders in the field. Particularly useful is the tabulation and nomenclature of the TCR[alpha] and [beta] variable regions and the inclusion of a plate section showing the alignments of these sequences."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Gamma Delta T Cells
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Author : Paul R. Bergstresser
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01
Gamma Delta T Cells written by Paul R. Bergstresser and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
Over the last 15 years, since the discovery of the T cell receptor and genes, rapid progress has been made toward the understanding of the biology of T cells. They differ from conventional T cells not only in T cell receptor composition, but also in their development, tissue distribution, and physiological functions. This volume contains seven chapters contributed by experts on different aspects of T cells, including the natural ligands for T cell receptors, IL-7-dependent regulation of T cell development, cytokine-mediated inter-cellular communication of T cells with other cell types, and their physiological functions in innate and adaptive immune responses. The comprehensive review articles collected in this volume will be of interest to basic immunologists who wish to update their knowledge on the biology of T cells. The book also provides a unique opportunity for non-immunologists and clinicians to understand how the immune system is specifically equipped to protect the body against pathogens at the environmental interface.
T Cell Receptor Signaling
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Author : Chaohong Liu
language : en
Publisher:
Release Date : 2020
T Cell Receptor Signaling written by Chaohong Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biochemistry categories.
This volume provides current and new advanced methods and protocols to study T cells. Chapters guide readers through T cell diversity using mass cytometry, analyzing T cells from single cell level, CRISPR/Cas9 techniques to study the T cell activation, techniques to study subsets of Tcell's, procedures to study artificial antigen presentosomes for T cell activation, techniques to study the T cell development, two-photon microscopy, and MAIT cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T-Cell Receptor Signaling: Methods and Protocols aims to provide a wide range of approaches and be an invaluable resource for present and future generations of T cell researchers.
T Lymphocytes And Their Receptors In Immunologic Recognition
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Author : Boris Davydovich Brondz
language : en
Publisher: CRC Press
Release Date : 1988
T Lymphocytes And Their Receptors In Immunologic Recognition written by Boris Davydovich Brondz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.