Evolution Adjusted Tumor Pathophysiology
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Evolution Adjusted Tumor Pathophysiology
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Author : Albrecht Reichle
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-01
Evolution Adjusted Tumor Pathophysiology written by Albrecht Reichle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-01 with Medical categories.
Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.
Evolution By Tumor Neofunctionalization
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Author : Andrei P. Kozlov
language : en
Publisher: Academic Press
Release Date : 2014-02-15
Evolution By Tumor Neofunctionalization written by Andrei P. Kozlov and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-15 with Science categories.
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology. Covers the role that tumors might play in evolution. Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more
Ppars In Cellular And Whole Body Energy Metabolism
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Author : Walter Wahli
language : en
Publisher: MDPI
Release Date : 2019-01-09
Ppars In Cellular And Whole Body Energy Metabolism written by Walter Wahli and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-09 with Biology (General) categories.
This book is a printed edition of the Special Issue "PPARs in Cellular and Whole Body Energy Metabolism" that was published in IJMS
Cancer Evolution
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Author : Charles Swanton
language : en
Publisher: Perspectives Cshl
Release Date : 2017
Cancer Evolution written by Charles Swanton and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Evolving Treatment Paradigms In Renal Cancer An Issue Of Urologic Clinics E Book
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Author : William C. Huang
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-05-08
Evolving Treatment Paradigms In Renal Cancer An Issue Of Urologic Clinics E Book written by William C. Huang and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-08 with Medical categories.
This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology. Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery. Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.
Ecology And Evolution Of Cancer
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Author : Beata Ujvari
language : en
Publisher: Academic Press
Release Date : 2017-02-08
Ecology And Evolution Of Cancer written by Beata Ujvari and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
Anticoagulation In Cardiovascular Diseases Evolving Role Unmet Needs And Grey Areas
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-02
Anticoagulation In Cardiovascular Diseases Evolving Role Unmet Needs And Grey Areas written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-02 with Medical categories.
Cancer Rnome Nature Evolution
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Author : Mansi Arora
language : en
Publisher: Springer
Release Date : 2018-11-02
Cancer Rnome Nature Evolution written by Mansi Arora and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Medical categories.
In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..
Molecular Genetic Pathology
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Author : Liang Cheng
language : en
Publisher: Springer
Release Date : 2013-03-05
Molecular Genetic Pathology written by Liang Cheng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-05 with Medical categories.
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Current Issues In Clinical Psychology
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Author : Eric Karas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Current Issues In Clinical Psychology written by Eric Karas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Psychology categories.
This is the third volume in the series of books based on the Annual Merseyside Course in Clinical Psychology. In common with its predecessors its aim is to present a number of topics of interest to practitioners, researchers, trainers and trainees in the field, with the intent not only to inform but variously also to question and to guide further enquiry. Selection for this volume has taken a somewhat different stance to the previous two. Whereas in former volumes an attempt has been made to cover standard areas of general and scientific interest to psychologists and others in related professions, such as anorexia nervosa, forensic issues, long term care, mental handicap, community psychology, anxiety and de pression, in this one issues which are of equal relevance but not necessarily of equal prominence in psychological texts, are included. We have not, however, neglected those areas more readily recognized as of major clinical import which are being progressively covered in this series. This year we have the section 'Bereavement and the Care of the Dying'. Although for many this may not be a main focus, it is a subject that few helpers do not encounter either directly or indirectly with their clients. It would be impossible for this subject to not reflect the most human side of the caring professions, and it is perhaps in this field that the objective/subjective dilemma of the clinician can be seen in its most acute form.