Ghrelin

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Ghrelin

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Author : Ezio Ghigo
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11

Ghrelin written by Ezio Ghigo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.

Ghrelin is a 28-amino acid acylated peptide predominatntly produced by the stomach. Highlights the impact and function of the hormone ghrelin and provides insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.

Central Functions Of The Ghrelin Receptor

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Author : Jeanelle Portelli
language : en
Publisher: Springer
Release Date : 2014-05-15

Central Functions Of The Ghrelin Receptor written by Jeanelle Portelli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-15 with Medical categories.

The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.

The Ghrelin System

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Author : A. Benso
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-04-22

The Ghrelin System written by A. Benso and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-22 with Medical categories.

The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin‚ a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure. Furthermore, ghrelin is the trigger for other neuroendocrine, metabolic and nonendocrine actions.This book, written by researchers who provided the major contributions to our current knowledge of this complex system, gives a comprehensive overview of the recent advances in ghrelin research. The hormone's influence on the cardiovascular, metabolic and gastroenteropancreatic system, hypothalamus-pituitary-adrenal axis, prolactin secretion, thyroid axis, gonadal axis as well as on behavior is discussed in detail. Furthermore, the clinical perspectives for ghrelin-derived therapeutic products are presented.Illustrating the tight inter-relationship between endocrinology, metabolism, cardiovascular disease and internal medicine, this book is essential reading for all scientists interested in appetite control, body weight and energy expenditure, as well as diabetes mellitus and neuroendocrinology.

Ghrelin

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Author :
language : en
Publisher: Elsevier
Release Date : 2007-11-08

Ghrelin written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-08 with Science categories.

First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Ghrelin In Health And Disease

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Author : Roy G. Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-02

Ghrelin In Health And Disease written by Roy G. Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-02 with Medical categories.

Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, the editors provide a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Hence, there is a need to combine information from basic translational research on ghrelin with results of clinical investigations. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.

Ghrelin Function Mechanism Of Action And Role In Health And Disease

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Author : Dennis Hertz
language : en
Publisher:
Release Date : 2020-03-30

Ghrelin Function Mechanism Of Action And Role In Health And Disease written by Dennis Hertz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-30 with categories.

Ghrelin is a 28-amino acid peptide mainly secreted by the stomach. To better understand the role of ghrelin signaling, Ghrelin: Function, Mechanism of Action and Role in Health and Disease first explores the regulation of age-associated adipose tissue inflammation. Following this, the authors discuss the influence of different variables on the response of short-term appetite regulation induced by exercise. External factors such as temperature and environment exert effects on hormonal responses, including hunger sensation and energy intake. The effects of gender differences and aging on psychological stress-dependent eating disorders are assessed, and the involvement of endogenous ghrelin, the serotonin 2c receptor and the estrogen alpha receptor is discussed. The penultimate chapter reviews the relationship between sleep and eating behavior, focusing in the influences of circadian changes on appetite related responses such as plasma concentration of ghrelin. The concluding study highlights the ghrelin system as a promising candidate for cardiovascular drug discovery, a new therapeutic approach for the treatment of endothelial impairment, and a possible contribution to the prevention of atherosclerosis.

A Compendium Of Multifaceted Role Of Ghrelin An Orexigenic Hormone

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Author : Dr.Hakim Saboowala
language : en
Publisher: Dr.Hakim Saboowala
Release Date : 2020-10-04

A Compendium Of Multifaceted Role Of Ghrelin An Orexigenic Hormone written by Dr.Hakim Saboowala and has been published by Dr.Hakim Saboowala this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-04 with Medical categories.

A Compendium of Multifaceted Role of Ghrelin: An Orexigenic Hormone. Ghrelin is a multifaceted gut hormone which activates its receptor, Growth Hormone Secretagogue Receptor (GHS-R). Ghrelin's hallmark functions are its stimulatory effects on food intake, fat deposition and growth hormone release. Ghrelin is famously known as the “hunger hormone”. However, ample literature indicates that the functions of ghrelin go well beyond its role as an orexigenic signal. Hence, an attempt has been made in this Booklet to focus on some of the most recent findings on Ghrelin (An Orexigenic Hormone) and its signaling (in animals and humans.) plays crucial roles in: · Glucose- and energy-homeostasis, · Cardio-protection, · Muscle atrophy, · Bone metabolism and · Cancer. Further, these multifaceted roles of ghrelin make ghrelin and GHS-R highly attractive targets for drug development. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Integrative Review Of Ghrelin Family Peptides Musculoskeletal Health And Osteoporotic Fractures

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Author : Leon Fisher
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2024-04-23

Integrative Review Of Ghrelin Family Peptides Musculoskeletal Health And Osteoporotic Fractures written by Leon Fisher and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-23 with Medical categories.

This book describes multiple effects of four stomach derived hormones (acylated and unacylated ghrelin, obestatin and nesfatin-1) collectively known as ghrelin family peptides (GFPs). The first part of the book focuses on known actions of GFPs under normal physiological conditions. Subsequent chapters describe the role of dysregulation in the production and action of these peptides in the complex network involved in numerous chronic diseases, musculoskeletal health, osteoporosis, falls and, consequently, osteoporotic fractures. The emerging data on the potential diagnostic and therapeutic benefits of GFPs in different disorders and implications on clinical practice is presented, and an extensive bibliography is provided.

The Ghrelin Receptor Gene In Animal Production

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Author : Yuki Fujimori
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2019-10-11

The Ghrelin Receptor Gene In Animal Production written by Yuki Fujimori and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Science categories.

Ghrelin and the ghrelin receptor (GHSR1a) play a central role in growth hormone secretion, food intake, energy metabolism, and other important functions. This book summarizes the present situation of the GHSR1a gene polymorphisms and their genetic effects on growth and fatty acid component traits in domestic animals, humans and rodents. It highlights a unique molecular evolution of the GHSR1a gene among animal species, and its significant genetic and epistatic effects on carcass and fatty acid component traits in a sex-dependent fashion. The volume also shows the overdominance effect of the GHSR1a-DelR242 locus on growth and its molecular mechanisms and the central role of the bovine GHSR1a_5’UTR-(TG) repeat locus in growth and fatty acid component traits in cattle.

Ghrelin

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Author : Hiromasa Yamada
language : en
Publisher: Nova Science Publishers
Release Date : 2012

Ghrelin written by Hiromasa Yamada and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Gastrointestinal hormones categories.

This book presents current research in the study of ghrelin, a gastric peptide hormone and neurotransmitter, which has been identified in the hypothalamus of the central nervous system, and has importance in food intake, body-weight regulation and glucose homeostasis. Topics discussed in this compilation include the pro-ghrelin derived peptides in iris muscle regulation and their implication in glaucoma pathophysiology; the expression, mechanisms of activity and role of ghrelin in the development of brain and neuronal networks; the role of central ghrelin in gastric accommodation and reflex swallowing and physiological relevance of ghrelin synthesis, transport and degradation.