Multimodal Biomarkers For Central Nervous System Disorders
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Multimodal Biomarkers For Central Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher:
Release Date : 2024-05-29
Multimodal Biomarkers For Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with categories.
A key step towards reducing the burden of central nervous system (CNS) disorders is the identification of disease-specific biomarkers that can help predict, monitor, and guide treatment development. Recent technological advances have led to an increased number of biomarkers for different CNS disorders, providing the opportunity to generate multimodal biomarkers. While multimodal biomarkers can serve as promising tools to better diagnose and make accurate disease assessments, there remain challenges in current data collection, standardization, and validation practices that impede in their development. Recognizing the need for increased CNS biomarker integration, the National Academies Forum on Neuroscience and Nervous System Disorders hosted a public workshop in March 2023 to explore steps toward this goal, including data collection for biomarker discovery, development, validation, and assessment of clinical utility. This Proceedings of a Workshop summarizes the discussions held during the workshop.
Biomarkers Of Neuroinflammation
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2018-03-16
Biomarkers Of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-16 with Medical categories.
Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
Neuroscience Biomarkers And Biosignatures
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2008-02-08
Neuroscience Biomarkers And Biosignatures written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-08 with Medical categories.
Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System
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Author : Forum on Neuroscience and Nervous System Disorders
language : en
Publisher:
Release Date : 2011-07-05
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System written by Forum on Neuroscience and Nervous System Disorders and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-05 with categories.
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Handbook Of Innovations In Central Nervous System Regenerative Medicine
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Author : António Salgado
language : en
Publisher: Elsevier
Release Date : 2020-06-10
Handbook Of Innovations In Central Nervous System Regenerative Medicine written by António Salgado and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-10 with Medical categories.
Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path
Objective Biometric Methods For The Diagnosis And Treatment Of Nervous System Disorders
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Author : Elizabeth B. Torres
language : en
Publisher: Academic Press
Release Date : 2018-06-29
Objective Biometric Methods For The Diagnosis And Treatment Of Nervous System Disorders written by Elizabeth B. Torres and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-29 with Medical categories.
Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders provides a new and unifying methodological framework, introducing new objective biometrics to characterize patterns of sensory motor control underlying symptoms. Its goal is to radically transform the ways in which disorders of the nervous system are currently diagnosed, tracked, researched and treated. This book introduces new ways to bring the laboratory to the clinical setting, to schools and to settings of occupational and physical therapy. Ready-to-use, graphic user interfaces are introduced to provide outcome measures from wearable sensors that automatically assess in near real time the effectiveness of interventions. Lastly, examples of how the new framework has been effectively utilized in the context of clinical trials are provided. Provides methods and implementation strategies using real data and simple computer programs that less technical students and researchers can utilize Contains appendices with computer code in MATLAB, along with data samples to generate graphics displayed on figures in each chapter Presents videos that illustrate the experimental setup for each situation/method described
Biomarkers To Enable Therapeutics Development In Neurodevelopmental Disorders
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Author : Mustafa Sahin
language : en
Publisher:
Release Date : 2020
Biomarkers To Enable Therapeutics Development In Neurodevelopmental Disorders written by Mustafa Sahin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Reviews On Biomarker Studies In Psychiatric And Neurodegenerative Disorders
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Author : Paul C. Guest
language : en
Publisher: Springer
Release Date : 2019-02-12
Reviews On Biomarker Studies In Psychiatric And Neurodegenerative Disorders written by Paul C. Guest and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-12 with Science categories.
This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Biochemical Biomarkers And Neurodegenerative Diseases
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Author : Marcello Ciaccio
language : en
Publisher: Mdpi AG
Release Date : 2021-11-04
Biochemical Biomarkers And Neurodegenerative Diseases written by Marcello Ciaccio and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-04 with Science categories.
In this book, we collected scientific articles, including reviews and research articles, showcasing the lastest literature on the importance of biochemical biomarkers in the management of neurodegenerative diseases, from screening to diagnosis, prognosis, and treatment.
Multimodal Magnetic Resonance Imaging Methods To Explore The Visual Pathway And Brain Network Changes In Blindness Disease
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Author : Yan Tong
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-09
Multimodal Magnetic Resonance Imaging Methods To Explore The Visual Pathway And Brain Network Changes In Blindness Disease written by Yan Tong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-09 with Science categories.