Neuroinflammation Resolution And Neuroprotection In The Brain
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Neuroinflammation Resolution And Neuroprotection In The Brain
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Author : Akhlaq A. Farooqui
language : en
Publisher: Academic Press
Release Date : 2021-09-15
Neuroinflammation Resolution And Neuroprotection In The Brain written by Akhlaq A. Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-15 with Medical categories.
Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. - Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection - Examines the role of diet and exercise on neuroinflammatory diseases - Provides cutting-edge research on signal transduction processes - Explores the treatment of neurological disorders caused by neuroinflammation
Natural Molecules In Neuroprotection And Neurotoxicity
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Author : Marcos Roberto de Oliveira
language : en
Publisher: Elsevier
Release Date : 2023-12-22
Natural Molecules In Neuroprotection And Neurotoxicity written by Marcos Roberto de Oliveira and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-22 with Science categories.
Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease. - Covers both neuroprotective and neurotoxic outcomes resulted from the exposure of brain cells to natural molecules - Analyzes numerous natural compounds, including animal, vegetal, fungal, bacterial, and marine-derived molecules - Discusses the effects of the metabolism of microbiota on the biotransformation of natural molecules and the consequences of these processes on brain cells - Contains a section focused on the nanotechnology-related strategies utilized to enhance the bioavailability of natural molecules to brain cells
Mechanisms Of Neuroinflammation And Inflammatory Neurodegeneration In Acute Brain Injury
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Author : Arthur Liesz
language : en
Publisher: Frontiers Media SA
Release Date : 2015-11-13
Mechanisms Of Neuroinflammation And Inflammatory Neurodegeneration In Acute Brain Injury written by Arthur Liesz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-13 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.
Synaptic Plasticity In Neurodegenerative Disorders
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Author : Sangeeta Singh
language : en
Publisher: CRC Press
Release Date : 2024-12-24
Synaptic Plasticity In Neurodegenerative Disorders written by Sangeeta Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Science categories.
This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's disease, Alzheimer's disease, and Huntington's disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases. Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies Presents tools and techniques used to simulate the complex system biology of synaptic plasticity Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.
Neuroinflammation And Cognition
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Author : Ashok Kumar
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-22
Neuroinflammation And Cognition written by Ashok Kumar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-22 with categories.
Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.
Neuroprotection
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Author : Matilde Otero-Losada
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-11-26
Neuroprotection written by Matilde Otero-Losada and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
Neuroinflammation
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Author : Samuel David
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-11
Neuroinflammation written by Samuel David and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-11 with Medical categories.
Neuroinflammation has long been studied for its connection to the development and progression of Multiple Sclerosis. In recent years, the field has expanded to look at the role of inflammatory processes in a wide range of neurological conditions and cognitive disorders including stroke, amyotrophic lateral sclerosis, and autism. Researchers have also started to note the beneficial impacts of neuroinflammation in certain diseases. Neuroinflammation: New Insights into Beneficial and Detrimental Functions provides a comprehensive view of both the detriments and benefits of neuroinflammation in human health. Neuroinflammation: New Insights into Beneficial and Detrimental Functions opens with two chapters that look at some fundamental aspects of neuroinflammation in humans and rodents. The remainder of the book is divided into two sections which examine both the detrimental and beneficial aspects of inflammation on the brain, spinal cord and peripheral nerves, on various disease states, and in normal aging. These sections provide a broad picture of the role neuroinflammation plays in the physiology and pathology of various neurological disorders. Providing cross-disciplinary coverage, Neuroinflammation: New Insights into Beneficial and Detrimental Functions will be an essential volume for neuroimmunologists, neurobiologists, neurologists, and others interested in the field.
Tau Oligomers
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Author : Jesus Avila
language : en
Publisher: Frontiers E-books
Release Date : 2014-08-18
Tau Oligomers written by Jesus Avila and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-18 with Medicine (General) categories.
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Mechanisms Of Innate Neuroprotection
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Author : Giuseppe Pignataro
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-27
Mechanisms Of Innate Neuroprotection written by Giuseppe Pignataro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Medicine (General) categories.
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
Neuroinflammation
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Author : Alireza Minagar
language : en
Publisher: Academic Press
Release Date : 2018-07-30
Neuroinflammation written by Alireza Minagar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-30 with Medical categories.
Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics. Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair. - Comprehensively reviews the latest developments in neuroinflammation and neuro-inflammatory diseases - Written for researchers and clinical practitioners in clinical neuroscience, neurology and immunology - Includes new chapters on Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury