Nitric Oxide From Research To Therapeutics
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Nitric Oxide From Research To Therapeutics
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Author : Arunabha Ray
language : en
Publisher: Springer Nature
Release Date : 2023-03-07
Nitric Oxide From Research To Therapeutics written by Arunabha Ray and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Medical categories.
This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics. The Editors are vastly experienced in the field of NO research. The international panels of contributors to the various chapters of the book are all well-established researchers and health professionals who have worked in different areas of NO physiology and pathophysiology, and have made a considerable impact in the field. The book is a comprehensive collection of the most recent information on NO as a physiological regulator and its diverse potential as a therapeutic target for the treatment for a variety of disease states. This compilation is aimed at professionals and students from both academia and the industry in the areas of basic biomedical and clinical sciences.
Nitric Oxide In Health And Disease
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Author : Jill Lincoln
language : en
Publisher: Cambridge University Press
Release Date : 1997-08-28
Nitric Oxide In Health And Disease written by Jill Lincoln and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-08-28 with Medical categories.
Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.
The Role Of Nitric Oxide In Heart Failure
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Author : Bodh I. Jugdutt
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
The Role Of Nitric Oxide In Heart Failure written by Bodh I. Jugdutt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Medical categories.
Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.
Nitric Oxide
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Author : Louis J. Ignarro
language : en
Publisher: Academic Press
Release Date : 2009-11-05
Nitric Oxide written by Louis J. Ignarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-05 with Science categories.
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Edited by Nobel Laureate Louis J. Ignarro Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
Pathophysiology And Clinical Applications Of Nitric Oxide
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Author : Gabor M. Rubanyi
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Pathophysiology And Clinical Applications Of Nitric Oxide written by Gabor M. Rubanyi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.
Nitric Oxide And The Cardiovascular System
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Author : Joseph Loscalzo
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-03-29
Nitric Oxide And The Cardiovascular System written by Joseph Loscalzo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-29 with Medical categories.
Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.
Nitric Oxide In Health And Disease
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Author : Lucia Morbidelli
language : en
Publisher: Elsevier
Release Date : 2023-04-28
Nitric Oxide In Health And Disease written by Lucia Morbidelli and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-28 with Computers categories.
Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical-nitric oxide-and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases.
Nitric Oxide
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Author : Helen O. McCarthy
language : en
Publisher: Humana Press
Release Date : 2010-12-16
Nitric Oxide written by Helen O. McCarthy and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Science categories.
The past two decades have seen an explosion in the number of research articles relating to both the physiological and pathological responses evoked by nitric oxide generation. Despite this, accurate quantification of nitric oxide in either in vitro or in vivo models remains challenging, due to the relatively unstable nature of the molecule. In Nitric Oxide: Methods and Protocols, experts in the field provide a detailed reference manual packed with step-by-step approaches to reproduce various complex protocols within your own laboratory. Divided into two parts, the volume first covers various disparate protocols relating to the direct detection and quantification of nitric oxide, including techniques which detail how to image real time in vivo generation of nitric oxide, quantify nitric oxide production in the rat brain, and the detect ultralow levels of nitric oxide in the pM range, and the book then continues with a section on techniques designed to either inhibit or enhance nitric oxide, with an aim to achieve therapeutic gain, featuring the inhibition of the nitric oxide synthase enzymes using viral, shRNA delivery systems to prevent cardiovascular dysfunction, peripheral neuropathy, and graft rejection. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Nitric Oxide: Methods and Protocols examines numerous complex methodologies detailed in each chapter and proves to be an invaluable resource for anyone with an interest in nitric oxide research.
Nitric Oxide Donors
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Author : Amedea Seabra
language : en
Publisher: Academic Press
Release Date : 2017-03-17
Nitric Oxide Donors written by Amedea Seabra and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-17 with Medical categories.
Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval
Nitric Oxide Protocols
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Author : Aviv Hassid
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Nitric Oxide Protocols written by Aviv Hassid and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Carrying on the high standards of the much-praised first edition of Nitric Oxide Protocols, Aviv Hassid has brought together a panel of expert researchers and clinician scientists to describe in step-by-step detail the latest methodologies for the measurement of nitric oxide--and the enzyme that produces it-in biological tissues and fluids. The authors take advantage of the latest methodologies for the quantitation of biological fluids and tissues, including capillary electrophoresis, microcoaxial electrodes, in vivo measurement of nitric oxide in exhaled air, confocal microscopy, gas chromatography, in situ hybridization, and real-time polymerase chain reaction. Chapters on the measurement of the novel products of nitric oxide, such as nitrated proteins, S-nitrosylated proteins, and dioxygen-dependent NO metabolism, are also included. Additional chapters address the expression of nitric oxide synthase via the use of viral vectors in gene therapy for erectile dysfunction and cancer, as well as in retrovirus, adenovirus, or adenoassociated virus-mediated expression of nitric oxide synthase in vivo. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Nitric Oxide Protocols, 2nd ed., offers investigators and clinican/scientists a gold-standard collection of readily reproducible analytical techniques for measuring levels of nitric oxide and determining its manifold functions and effects.