Non Coding Rnas In Complex Diseases

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Non Coding Rnas In Complex Diseases

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Author : Xia Li
language : en
Publisher: Springer
Release Date : 2018-09-06

Non Coding Rnas In Complex Diseases written by Xia Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-06 with Computers categories.

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas. Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Non Coding Rnas In Complex Diseases

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Author : Xia Li
language : en
Publisher:
Release Date : 2018

Non Coding Rnas In Complex Diseases written by Xia Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Genetic disorders categories.

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases

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Author : Mohammadreza Hajjari
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-14

Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases written by Mohammadreza Hajjari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-14 with Genetics categories.

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.

Regulation By Non Coding Rnas Volume 1

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Author : Nicholas Delihas
language : en
Publisher: MDPI
Release Date : 2018-10-09

Regulation By Non Coding Rnas Volume 1 written by Nicholas Delihas and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-09 with Non-coding RNA. categories.

Printed Edition of the Special Issue Published in IJMS

Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders

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Author : Yingqun Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-21

Emerging Roles Of Long Noncoding Rnas In Neurological Diseases And Metabolic Disorders written by Yingqun Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-21 with Biology (General) categories.

Long noncoding RNAs (lncRNAs) are a new class of transcripts that are in general longer than 200 nucleotides and that have no protein-coding potential. The vast majority of vertebrate genomes encode diverse and complex lncRNAs that play regulatory roles at almost every step of gene expression. Recently, increasing evidence has implicated lncRNAs in the pathogenesis of various human diseases. The purpose of the Research Topic, "Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders", is to bring together leading researchers in the field who, through contributing to an organized and comprehensive collection of peer-reviewed articles, provide a broad perspective on the latest advances in the field. A number of interesting and cutting-edge areas will be covered as below, but this list is not exclusive: - The methodologies and technologies of identifying and studying lncRNAs - LncRNAs in gene-specific transcription - LncRNAs in epigenetic regulation - LncRNAs in post-transcriptional regulation - LncRNAs in disease - Mapping of noncoding single nucleotide polymorphisms associated with disease.

Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease

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Author : Amanda Salviano-Silva
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-11

Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease written by Amanda Salviano-Silva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-11 with Science categories.

Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition

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Author : Yun Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-04

Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition written by Yun Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Science categories.

Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778

Long Non Coding Rnas In Human Disease

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Author : Kevin V. Morris
language : en
Publisher: Springer
Release Date : 2016-04-13

Long Non Coding Rnas In Human Disease written by Kevin V. Morris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-13 with Medical categories.

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Non Coding Rnas And Human Diseases

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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08

Non Coding Rnas And Human Diseases written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.

Long Non Coding Rnas Function Mechanisms And Applications

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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2025-07-02

Long Non Coding Rnas Function Mechanisms And Applications written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-02 with Science categories.

LncRNAs contribute to cancer progression by regulating gene expression epigenetically and post-transcriptionally. They influence tumorigenesis through interactions with chromatin modifiers, act as competitive endogenous RNAs to modulate microRNA activity and regulate processes such as epithelial-mesenchymal transition (EMT) that facilitate metastasis. LncRNAs affect cancer cell proliferation, apoptosis, migration, metabolism, and drug resistance, making them crucial players in tumor development and potential targets for diagnosis and therapy. The book covers the latest reports about lncRNAs.