Revisiting The Thymus The Origin Of T Cells
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Revisiting The Thymus The Origin Of T Cells
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Author : Yayi Gao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-04
Revisiting The Thymus The Origin Of T Cells written by Yayi Gao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-04 with Medical categories.
Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential
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Author : B. Kyewski
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-09
Cd4 Cd25 Regulatory T Cells Origin Function And Therapeutic Potential written by B. Kyewski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-09 with Medical categories.
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
A Living History Of Immunology
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Author : Kendall Arthur Smith
language : en
Publisher: Frontiers Media SA
Release Date : 2015-11-04
A Living History Of Immunology written by Kendall Arthur Smith and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-04 with Electronic book categories.
In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
The Song Of The Cell
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Author : Siddhartha Mukherjee
language : en
Publisher: Random House
Release Date : 2022-11-03
The Song Of The Cell written by Siddhartha Mukherjee and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Science categories.
**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR** From the dawn of life itself, every being that has ever lived owes its existence to the cell. 'Will leave you in awe' Guardian The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether. Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better. 'Profound...As big a topic as life itself' The Times 'Medical magic' Daily Telegraph 'Vast...important...optimistic' Mail on Sunday
Fetal Embryonic Hematopoietic Progenitors And Their Impact On Adult Diseases
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Author : Silvia Brunelli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-01
Fetal Embryonic Hematopoietic Progenitors And Their Impact On Adult Diseases written by Silvia Brunelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-01 with Science categories.
Revisiting Behavioral Variability What It Reveals About Neural Circuit Structure And Function
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Author : Kenta Asahina
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-23
Revisiting Behavioral Variability What It Reveals About Neural Circuit Structure And Function written by Kenta Asahina and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-23 with Science categories.
Regulatory T Cells In Inflammation
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Author : Leonie S. Taams
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30
Regulatory T Cells In Inflammation written by Leonie S. Taams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Medical categories.
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Artificial Immune Systems A New Computational Intelligence Approach
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Author : Leandro Nunes de Castro
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-09-23
Artificial Immune Systems A New Computational Intelligence Approach written by Leandro Nunes de Castro and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-23 with Computers categories.
Artificial Immune Systems (AIS) are adaptive systems inspired by the biological immune system and applied to problem solving. This book provides an accessible introduction that will be suitable for anyone who is beginning to study or work in this area. It gives a clear definition of an AIS, sets out the foundations of the topic (including basic algorithms), and analyses how the immune system relates to other biological systems and processes. No prior knowledge of immunology is needed - all the essential background information is covered in the introductory chapters. Key features of the book include: - A discussion of AIS in the context of Computational Intelligence; - Case studies in Autonomous Navigation, Computer Network Security, Job-Shop Scheduling and Data Analysis =B7 An extensive survey of applications; - A framework to help the reader design and understand AIS; - A web site with additional resources including pseudocodes for immune algorithms, and links to related sites. Written primarily for final year undergraduate and postgraduate students studying Artificial Intelligence, Evolutionary and Biologically Inspired Computing, this book will also be of interest to industrial and academic researchers working in related areas.
Stem Cells In Regenerative Medicine
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Author : Alain A. Vertes
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-14
Stem Cells In Regenerative Medicine written by Alain A. Vertes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with Science categories.
This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.
Philosophy Of Immunology
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Author : Thomas Pradeu
language : en
Publisher: Cambridge University Press
Release Date : 2020-02-13
Philosophy Of Immunology written by Thomas Pradeu and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-13 with Science categories.
Immunology is central to contemporary biology and medicine, but it also provides novel philosophical insights. Its most significant contribution to philosophy concerns the understanding of biological individuality: what a biological individual is, what makes it unique, how its boundaries are established and what ensures its identity through time. Immunology also offers answers to some of the most interesting philosophical questions. What is the definition of life? How are bodily systems delineated? How do the mind and the body interact? In this Element, Thomas Pradeu considers the ways in which immunology can shed light on these and other important philosophical issues. This title is also available as Open Access on Cambridge Core.