Bisphosphonates And Tumor Osteolysis
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Bisphosphonates And Tumor Osteolysis
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Author : Kurt W. Brunner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Bisphosphonates And Tumor Osteolysis written by Kurt W. Brunner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume informs the reader about basic chemical and experimental aspects of the bisphosphonates, their application in neoplastic hypercalcemia, and the basic effects of these drugs in neoplastic osteolysis. Initial reports, which need confirmation by larger randomized studies, also deal with the long-term application and possibly favorable influence of bisphosphonates in metastatic bone disease. It is vital for medical oncologists and interested internists to keep abreast of recent information in this new area of clinical cancer research.
Tumor Bone Diseases And Osteoporosis In Cancer Patients
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Author : Jean-Jac Body
language : en
Publisher: CRC Press
Release Date : 1999-10-22
Tumor Bone Diseases And Osteoporosis In Cancer Patients written by Jean-Jac Body and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-22 with Medical categories.
With bone metastases found to develop in more than half of patients with advanced cancers, this remarkable reference sheds much-needed light on the relation of various cancers-particularly breast and prostate cancer and multiple myeloma-to bone morbidity. The book addresses new therapies that can reduce the frequency of morbid skeletal events by as much as half. Examines cancer's effects on bone tissue from pathophysiological, diagnostic, monitoring, and therapeutic points of view! Written by more than 40 international experts in the field, Tumor Bone Diseases and Osteoporosis in Cancer Patients reviews the basics of bone physiology investigates the propensity of breast cancer cells to metastasize in bone due primarily to the abundance of growth factors in the skeletal microenvironment-strongly supporting the seed-and-soil hypothesis of the metastatic process discusses the efficacy of local radiotherapy and radioactive isotopes in treating bone metastases covers endocrine and chemotherapy trials on patients with bone metastases explores osteoclast activation and direct osteolytic effects of metastatic cancer cells evaluates the noncytotoxic treatments of bisphosphonates as potent inhibitors of osteoclast-mediated bone resorption assesses bisphosphonates as agents for ameliorating pain and preventing metastases in cancer patients describes preventive therapy against osteoporosis and more! Containing over 1700 references and more than 200 tables, drawings, and micrographs, Tumor Bone Diseases and Osteoporosis in Cancer Patients is a first-rank resource for medical, surgical, and clinical oncologists and radiotherapists, endocrinologists, internists, biologists, biochemists, and graduate and medical school students in these disciplines.
Bisphosphonates In Clinical Oncology
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Author : Beat Thürlimann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Bisphosphonates In Clinical Oncology written by Beat Thürlimann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology. The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as the results of pivotal studies. New important findings on how to best use pamidronate in certain indications are given and put in perspective. The author discusses patient management guidelines as well as pharmaco-economic aspects important for the readers.
Bisphosphonates And Metastatic Bone Disease
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Author : R. D. Rubens
language : en
Publisher: Parthenon Publishing
Release Date : 1994
Bisphosphonates And Metastatic Bone Disease written by R. D. Rubens and has been published by Parthenon Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Bone metastasis categories.
Bisphosphonates In Bone Disease
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Author : Herbert Fleisch
language : en
Publisher: Elsevier
Release Date : 2000-04-18
Bisphosphonates In Bone Disease written by Herbert Fleisch and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-18 with Medical categories.
This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. * The revised fourth edition contains approximately 50% new material * Includes information on all the latest drugs
Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach
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Author : Francesco Saverio De Ponte
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-25
Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach written by Francesco Saverio De Ponte and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-25 with Medical categories.
During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.
Osteolysis New Insights For The Healthcare Professional 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Osteolysis New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Osteolysis: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Osteolysis in a compact format. The editors have built Osteolysis: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Osteolysis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Osteolysis: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Bisphosphonates In Medical Practice
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Author : Reiner Bartl
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-14
Bisphosphonates In Medical Practice written by Reiner Bartl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-14 with Medical categories.
Bones are everybody’s business. This means that clinical osteology, now an independent specialty, nevertheless encompasses all branches of medicine and affects each and every one of us. Intended for doctors who seek precise information on bisphosphonates in medical practice, this book has been designed as an up-to-date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment.
Pocket Guide To Bisphosphonates In Clinical Practice
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Author : R. Bartl
language : en
Publisher: Wiley-Blackwell
Release Date : 2002-02-08
Pocket Guide To Bisphosphonates In Clinical Practice written by R. Bartl and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-08 with Medical categories.
The potential capacity of the biphosphonates to intervene in osseous remodeling was recognized more than 30 years ago. The biphosphonates inhibit osteoclastic activity. In spite of advances in early detection, surgey, chemo-and radiotherapy, metastatic bone disease is still a major and in many cases intractable clinical problem. The biphosphonates are now the most effective agents in the management of bone metastases - as shown by trials in patients with breast and prostate cancer, and in multiple myeloma. Bone pain, new ostelytic events and pathologic fractures are decreased and complications associated with these events are avoided. Existing osteolytic lesions may even be reversed. New fields of indications of biphosphonates are shown to be in the adjuvant therapy of breast cancer and in stage 1 multiple myeloma to prevent skeletal destruction and also to inhibit tumor growth. Over the past few years the biphosphonates have proved their value also in many other conditions such as Paget's disease of bone, osseous disorders with an osteoclastic component leading to osteopenia/osteoporosis, in congenial, endocrine and metabolic disorders. Perhaps, for the future and for the next millennium the most widespread and extensive use to these anti-osteoclastic component leading to osteopenia/osteoporosis, in congenial, endocrine and metabolic disorders. Perhaps, for the future and for the next millennium the most widespread and extensive use to these anti-osteoclastic agents will be in these disorders, and particularly in so-called primary osteoporosis which evenually effects anyone who lives long enough, causing widespread morbidity with drastic economic consequences both individually and nationally. The authors' aim is to provide an office and desk companion - comprehensive, concise, practical for easy reference - an up-to-date guide for prevention and therapy of skeletal complications whenever and wherever they occur in general and specialized medical practice.
Cancer Related Bone Pain
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Author : Andrew Davies
language : en
Publisher: Oxford University Press
Release Date : 2007-11-15
Cancer Related Bone Pain written by Andrew Davies and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-15 with Medical categories.
Cancer-related bone pain is experienced by patients with primary bone tumours such as myeloma and osteosarcoma, but is more commonly seen in patients with malignant tumours that have metastasised to bone. Bone pain is one of the most common and severe forms of pain associated with breast, prostate and lung cancer, yet little is known about the underlying mechanisms responsible for the pain. Cancer patients identify bone pain as the most disruptive cancer-related event in terms oftheir quality of life and daily functioning, and it is also associated with increased incidence of morbidity, depression, and anxiety.Part of the Oxford Pain Management Library, this volume summarises the latest evidence-based and practical information on the management of cancer-related bone pain. Chapters cover the pathophysiology and clinical features of bone pain, general principles of management and the use of opioids and other agents. It will be an invaluable reference for all health care professionals involved in the management of patients with bone pain from various disciplines including palliative care,anaesthetics, oncology and general practice.