In Vitro Models Of Alzheimer S Disease
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In Vitro Models Of Alzheimer S Disease
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Author :
language : en
Publisher:
Release Date : 2002
In Vitro Models Of Alzheimer S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
An In Vitro Model For Alzheimer S Disease Pathology
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Author : Gregory Michael Cole
language : en
Publisher:
Release Date : 1986
An In Vitro Model For Alzheimer S Disease Pathology written by Gregory Michael Cole and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Therapeutic Targets For Alzheimer S Disease
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Author : Magdalena J. Kiprowska
language : en
Publisher:
Release Date : 2016
Therapeutic Targets For Alzheimer S Disease written by Magdalena J. Kiprowska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Genedis 2018
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Author : Panayiotis Vlamos
language : en
Publisher: Springer Nature
Release Date : 2020-05-28
Genedis 2018 written by Panayiotis Vlamos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-28 with Medical categories.
The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders
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Author : Adeboye Adejare
language : en
Publisher: Academic Press
Release Date : 2016-09-20
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders written by Adeboye Adejare and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Medical categories.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
Amyloidogenesis And The Cholinergic System In Alzheimer S Disease
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Author : Fracisca C. Bronfman
language : en
Publisher:
Release Date : 2000-10-01
Amyloidogenesis And The Cholinergic System In Alzheimer S Disease written by Fracisca C. Bronfman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-01 with Medical categories.
Conformational Studies Of The Beta Amyloid Protein And In Vitro Models For The Effects Of Apolipoprotein E On Fibril Formation In Alzheimer S Disease
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Author : Krista Carole Evans
language : en
Publisher:
Release Date : 1996
Conformational Studies Of The Beta Amyloid Protein And In Vitro Models For The Effects Of Apolipoprotein E On Fibril Formation In Alzheimer S Disease written by Krista Carole Evans and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Establishment Of An In Vitro Alzheimer S Disease Model System
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Author : Chad Edward Branecki
language : en
Publisher:
Release Date : 1999
Establishment Of An In Vitro Alzheimer S Disease Model System written by Chad Edward Branecki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Alzheimer's disease categories.
Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy
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Author : Gilda Shayan
language : en
Publisher:
Release Date : 2010
Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy written by Gilda Shayan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Currently, there are over 5.3 million people in the United States diagnosed with Alzheimer's disease, with the disease being the sixth leading cause of death in the country. Current drugs on the market for the treatment of Alzheimer's disease are lipophilic small molecules that cross the blood-brain barrier by passive diffusion and none have been clinically useful in reversing the symptoms of the disease. Immunotherapy with intravenous immunoglobulin (IVIg) is one of several treatment strategies now being studied as part of efforts to discover safe and more effective treatment paradigms for Alzheimer's disease. In 2005, Weill Cornell Medical College initiated the phase I clinical trial of IVIg for the treatment of Alzheimer's disease, and the clinical outcomes indicated improvements in the cognitive abilities of subjects beyond expectations. This dissertation will address combining proteomics and statistical approaches with novel designs for in vitro blood-brain barrier models with an attempt to understand the molecular basis for the disease-modifying effects of IVIg in Alzheimer's disease. The first part of the thesis focuses on the development of a new in vitro model of the blood-brain barrier based on a co-culture between primary mouse brain microvascular endothelial cells and primary rat astrocytes on commercially available polyester membranes and nanofabricated poly(hydroxyl styrene) membranes. This model serves as a successful platform technology for evaluating molecular transport across the blood-brain barrier. The permeability of central nervous system drugs across this in vitro model correlated well with in vivo data, with the correlation coefficient being 0.98. The second part of this thesis provides examples of proteomics approaches coupled with advanced statistical modeling that can be utilized to identify therapy induced biomarkers in the cerebrospinal fluid. Specifically, cerebrospinal fluid samples from Alzheimer's subjects who underwent IVIg immunotherapy were analyzed using gel-based proteomics and the results were analyzed using a statistical model to identify 25 therapeutically relevant biomarkers in response to IVIg. These proteins have been previously implicated in Alzheimer's disease and the changes in their concentration is consistent with previous reports regarding the expression of them in the brain of Alzheimer's subjects compared to normal individuals.
Examining Nrf2 Expression As A Potential Therapy For Alzheimer S Disease Using An In Vitro Cell Model
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Author : Wenyuan Wei
language : en
Publisher:
Release Date : 2020
Examining Nrf2 Expression As A Potential Therapy For Alzheimer S Disease Using An In Vitro Cell Model written by Wenyuan Wei and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Alzheimer's disease (AD) is a neurodegenerative condition that contributes to the majority of dementia cases worldwide. The exact cause of AD remains elusive, and the study of its disease biology is hampered by the lack of in vitro and in vivo models that are representative of the condition, and the absence of disease-modifying treatments. In this project, we attempted to use the most accurate cellular model of AD currently available to test whether an intervention that reduces oxidative stress, a common pathological feature of AD, can provide therapeutic benefits. The cellular model we used is a 3-dimensional cell matrix formed by differentiated immortalized human neural-progenitors which was previously shown to generate many key feature of AD pathobiology, such as phosphorylated Tau and Ab aggregates. Our therapeutic intervention was the overexpression of Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor that counters oxidative stress in normal cells and was found to ameliorate the symptoms of AD in mice. This project first made an attempt to reproduce the 3-dimensional AD cell culture model, and then test the effectiveness of NRF2 overexpression as a treatment option.