Reprogramming The Cellular Molecular And Metabolic Architecture Of The Tumor Microenvironment For Effective Cancer Immunotherapy
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Reprogramming The Cellular Molecular And Metabolic Architecture Of The Tumor Microenvironment For Effective Cancer Immunotherapy
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Author : Soumen Chakraborty
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-16
Reprogramming The Cellular Molecular And Metabolic Architecture Of The Tumor Microenvironment For Effective Cancer Immunotherapy written by Soumen Chakraborty and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-16 with Medical categories.
Reviews In Molecular And Cellular Oncology
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Author : Daniel P. Bezerra
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-06
Reviews In Molecular And Cellular Oncology written by Daniel P. Bezerra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Medical categories.
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
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Author : Patrik Andersson
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy written by Patrik Andersson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus
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Author : Wantao Wu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Unveiling Biomarkers And Mechanisms In The Tumor Immune Nexus written by Wantao Wu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
The interplay between cancer cells and the immune system is a critical area of research, with recent advancements highlighting the potential of immunotherapy in offering durable responses across various cancer types. Immune checkpoint inhibitors, in particular, have emerged as a cornerstone of cancer therapy, transforming patient outcomes. However, the heterogeneity of tumor-immune interactions poses significant challenges, with a considerable fraction of patients not responding to such treatments. This underscores the urgent need for a deeper understanding of the molecular and cellular underpinnings of these interactions, to harness the full potential of immunotherapy. This Research Topic aims to address the complex landscape of tumor-immune interactions, focusing on identifying and leveraging novel biomarkers and mechanisms that can predict and enhance the efficacy of immunotherapy. Given the pivotal role of the immune system in controlling and eradicating cancer, understanding these interactions at a granular level could lead to more personalized and effective treatment strategies. Recent advances in technologies such as next-generation sequencing, single-cell RNA sequencing, and mass cytometry have opened new avenues for dissecting the complexity of the tumor microenvironment and immune evasion strategies. This collection seeks to compile cutting-edge research that employs these technologies to uncover new biomarkers, understand resistance mechanisms, and identify potential therapeutic targets within the immune contexture of tumors. By bridging gaps in knowledge and fostering innovation, this topic aims to propel the field towards more predictive and responsive immunotherapy approaches.
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii
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Author : Liang Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-29
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii written by Liang Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Science categories.
Community Series In Manipulating The Immunological Tumor Microenvironment Volume Ii
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Author : Huanfa Yi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-17
Community Series In Manipulating The Immunological Tumor Microenvironment Volume Ii written by Huanfa Yi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-17 with Medical categories.
Tata Memorial Centre Textbook Of Oncology
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Author : Rajendra A. Badwe
language : en
Publisher: Springer Nature
Release Date : 2024-08-29
Tata Memorial Centre Textbook Of Oncology written by Rajendra A. Badwe and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-29 with Medical categories.
The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.
Tumor Microenvironment
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Author : Jacinta Serpa
language : en
Publisher: Springer Nature
Release Date : 2020-03-04
Tumor Microenvironment written by Jacinta Serpa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Medical categories.
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Preclinical Models And Emerging Technologies To Study The Effects Of The Tumor Microenvironment On Cancer Heterogeneity And Drug Resistance
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Author : Giulia Adriani
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-26
Preclinical Models And Emerging Technologies To Study The Effects Of The Tumor Microenvironment On Cancer Heterogeneity And Drug Resistance written by Giulia Adriani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-26 with Medical categories.
Modulation Of T Cell Function And Survival By The Tumor Microenvironment
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Author : Shahrzad Jalali
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-26
Modulation Of T Cell Function And Survival By The Tumor Microenvironment written by Shahrzad Jalali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Science categories.